Understanding Gaps and Limitations in Current ITP Therapies

EP: 1.Understanding Immune Thrombocytopenia: Pathophysiology, Classification, and Differentiation

EP: 2.Diagnostic and Patient Education Strategies in ITP

EP: 3.Managing Bleeding Risk in Patients with ITP

EP: 4.Living with ITP: Impact of Fatigue and Other Symptoms on Patients’ Quality of Life

EP: 5.Tailoring Care in ITP Through a Health Equity Lens

EP: 6.Looking Ahead in ITP: Addressing Unmet Needs and Embracing Innovation

EP: 7.Key Clinical Signs and Symptoms Used in Diagnosis of Immune Thrombocytopenia

EP: 8.Clinical Decision-Making in ITP: Timing Treatment Initiation and Therapy Goals

EP: 9.Current Treatment Algorithm for Management of Immune Thrombocytopenia

EP: 10.Addressing the Limitations of Current ITP Therapies

EP: 11.Risks versus Benefits: ITP Treatment Side Effects and the Influence on Patients’ Quality of Life

EP: 12.Defining Treatment Success, Failure, and When to Reassess Patients’ Management of ITP

EP: 13.Navigating Refractory ITP: Clinical Insights and Treatment Strategies

EP: 14.Potential Impact of Emerging Therapies on Patients Living with ITP

EP: 15.Emerging Agents Reshaping the ITP Landscape

Now Viewing

EP: 16.Understanding Gaps and Limitations in Current ITP Therapies

Individuals living with ITP face significant challenges with existing treatment options that extend beyond bleeding prevention. Current standard therapies, including corticosteroids, present considerable tolerability issues for patients, such as elevated blood glucose, high blood pressure, sleep disruption, and cognitive impairment. Rituximab requires intravenous administration and can leave patients vulnerable to infections through prolonged immunosuppression, whereas fostamatinib causes hypertension, diarrhea, and potential bleeding complications.

Beyond these safety concerns, current ITP treatments fail to provide sustained platelet responses for many patients. Intravenous immunoglobulin and anti-D therapies offer only temporary improvements without long-term durability. This lack of sustained efficacy creates ongoing management challenges for individuals managing this chronic autoimmune condition.

Quality of life represents a critical unmet need that existing therapies inadequately address. Patients with ITP experience fatigue, reduced daily functioning, and gender-specific health impacts that persist even when platelet counts improve. For individuals with diabetes, corticosteroid-induced hyperglycemia poses particular risks, whereas those at risk for blood clots face complicated decisions regarding thrombopoietin receptor agonists. Premenopausal women specifically struggle with quality-of-life impacts that current treatments fail to address, highlighting the urgent need for therapies that target both disease mechanisms and patient well-being comprehensively.