Catherine M. Broome, MD, discusses how immune thrombocytopenia (ITP) is diagnosed, classified, and managed, including bleeding risk assessment, quality of life impacts, personalized treatment approaches, and future directions for addressing this heterogeneous autoimmune disorder that causes low platelet counts.
EP. 1: Understanding Immune Thrombocytopenia: Pathophysiology, Classification, and Differentiation
May 30th 2025A panelist discusses how immune thrombocytopenia (ITP) is characterized by isolated low platelet counts due to autoimmune destruction, with classification based on duration (acute, extended, or chronic) and severity of thrombocytopenia.
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EP. 2: Diagnostic and Patient Education Strategies in ITP
June 6th 2025A panelist discusses how ITP diagnosis remains one of exclusion requiring thorough testing to rule out other causes of thrombocytopenia, followed by patient education about autoimmune diseases and bleeding symptoms like nosebleeds, bruising, and petechiae.
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EP. 4: Living with ITP: Impact of Fatigue and Other Symptoms on Patients’ Quality of Life
June 20th 2025A panelist discusses how ITP creates a chronic inflammatory state causing underrecognized symptoms like fatigue and joint pain that significantly impact patients' quality of life and ability to function, while recommending avoidance of activities that could cause head or internal injuries.
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EP. 5: Tailoring Care in ITP Through a Health Equity Lens
June 27th 2025A panelist discusses how personalized ITP care requires open conversations about testing costs, insurance coverage, and treatment accessibility, with clinicians helping patients navigate financial barriers through pharmaceutical assistance programs and clinical trials.
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EP. 6: Looking Ahead in ITP: Addressing Unmet Needs and Embracing Innovation
July 4th 2025A panelist discusses how personalized ITP care requires open conversations about testing costs, insurance coverage, and treatment accessibility, with clinicians helping patients navigate financial barriers through pharmaceutical assistance programs and clinical trials.
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EP. 7: Key Clinical Signs and Symptoms Used in Diagnosis of Immune Thrombocytopenia
July 31st 2025An expert discusses the clinical presentation and diagnosis of immune thrombocytopenic purpura (ITP), emphasizing that isolated thrombocytopenia with mucosal bleeding and petechiae is highly suggestive of ITP, while underscoring the importance of ruling out other causes—especially drug-induced thrombocytopenia—through careful evaluation.
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EP. 8: Clinical Decision-Making in ITP: Timing Treatment Initiation and Therapy Goals
July 31st 2025An expert discusses treatment strategies for immune thrombocytopenic purpura (ITP), emphasizing individualized decisions based on platelet count, bleeding symptoms, and comorbidities, with options ranging from observation to urgent therapies like steroids or IVIG, and longer-term approaches tailored to patient health, treatment goals, and lifestyle considerations.
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EP. 9: Current Treatment Algorithm for Management of Immune Thrombocytopenia
August 7th 2025An expert discusses treatment strategies for immune thrombocytopenic purpura (ITP), emphasizing individualized decisions based on platelet count, bleeding symptoms, and comorbidities, with options ranging from observation to urgent therapies like steroids or IVIG, and longer-term approaches tailored to patient health, treatment goals, and lifestyle considerations.
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EP. 10: Addressing the Limitations of Current ITP Therapies
August 7th 2025An expert discusses the importance of patient education and personalized, flexible treatment planning in managing chronic immune thrombocytopenic purpura (ITP), highlighting proactive strategies like emergency steroids, shared decision-making, and interdisciplinary care to align therapy choices with each patient’s lifestyle, preferences, and comorbidities.
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An expert discusses the importance of balancing efficacy with safety in ITP treatment, emphasizing cautious use of steroids, close monitoring of therapy-related side effects, and maintaining platelet counts just above bleeding thresholds to minimize long-term drug toxicity through personalized, informed care.
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EP. 12: Defining Treatment Success, Failure, and When to Reassess Patients’ Management of ITP
August 14th 2025An expert discusses how ITP treatment success is monitored through maintaining safe platelet levels and symptom control, managing relapses, and tailoring follow-up based on therapy type and patient needs.
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EP. 13: Navigating Refractory ITP: Clinical Insights and Treatment Strategies
August 21st 2025An expert discusses the expanded treatment options for refractory ITP, emphasizing accurate diagnosis, combination therapies targeting platelet production and destruction, and the evolving role of splenectomy with improved safety measures.
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EP. 14: Potential Impact of Emerging Therapies on Patients Living with ITP
August 21st 2025An expert discusses the rapidly evolving landscape of ITP treatments, highlighting emerging therapies such as Bruton’s tyrosine kinase inhibitors, neonatal Fc receptor antagonists, anti-CD38 antibodies, and innovative approaches like CAR T-cell therapy that offer new hope for improved patient outcomes.
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