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Making LDL Matter Again: Addressing Clinical, Patient, and Payer Barriers in ASCVD Management : Episode 14
Cumulative LDL-C Exposure
Panelists discuss how long-term LDL-C exposure heightens cardiovascular risk, making early and sustained lowering crucial.
EP: 1.Understanding the Current State of LDL-C Goal Attainment and Barriers to Adequate Control in Hyperlipidemia
EP: 2.Challenges with Undertreatment in Hyperlipidemia and Opportunities to Address this Gap
EP: 3.Pharmacy-Driven Challenges
EP: 4.Real-World Insights and PROMPT-LIPID
EP: 5.Social Determinants of Health
EP: 6.The 2013 Guideline Shift
EP: 7.Unintended Consequences of Metric Changes
EP: 8.Reinstating LDL-C Targets
EP: 9.International LDL Thresholds
EP: 10.Nonstatin Therapy Decisions
EP: 11.PCSK9 Inhibitor Underuse
EP: 12.Payer and Prior Authorization Barriers
EP: 13.Adherence and Persistence
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EP: 14.Cumulative LDL-C Exposure
EP: 15.Economic Burden and Systemwide Strategies
Panelists discuss how cumulative low-density lipoprotein cholesterol (LDL-C) exposure compounds cardiovascular risk over time, underscoring the importance of early and sustained lowering. The “lower for longer” approach correlates strongly with reduced event rates.
They explain that each year of uncontrolled LDL-C contributes to plaque progression and irreversible vascular damage.
Panelists advocate for earlier initiation of therapy, proactive intensification, and lifelong adherence to minimize cumulative exposure.
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