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Making LDL Matter Again: Addressing Clinical, Patient, and Payer Barriers in ASCVD Management : Episode 9
International LDL Thresholds
Panelists discuss how global LDL thresholds below 55 mg/dL influence care and challenge U.S. practice to evolve.
EP: 1.Understanding the Current State of LDL-C Goal Attainment and Barriers to Adequate Control in Hyperlipidemia
EP: 2.Challenges with Undertreatment in Hyperlipidemia and Opportunities to Address this Gap
EP: 3.Pharmacy-Driven Challenges
EP: 4.Real-World Insights and PROMPT-LIPID
EP: 5.Social Determinants of Health
EP: 6.The 2013 Guideline Shift
EP: 7.Unintended Consequences of Metric Changes
EP: 8.Reinstating LDL-C Targets
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EP: 9.International LDL Thresholds
EP: 10.Nonstatin Therapy Decisions
EP: 11.PCSK9 Inhibitor Underuse
EP: 12.Payer and Prior Authorization Barriers
EP: 13.Adherence and Persistence
EP: 14.Cumulative LDL-C Exposure
EP: 15.Economic Burden and Systemwide Strategies
Panelists discuss how international guidelines—particularly European ones—have adopted aggressive low-density lipoprotein (LDL) thresholds below 55 mg/dL for high-risk patients. These approaches have driven measurable improvements in cardiovascular outcomes abroad.
The conversation examines whether the US should follow suit, balancing clinical benefit against cost, feasibility, and patient adherence.
Panelists agree that while uniform LDL standards could reduce confusion, US implementation would require payer alignment and system-wide commitment.
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