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A panel of experts suggests adding caplacizumab to the historic treatment of plasma exchange and immunosuppression could lead to significant improvement in outcomes for patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP).

The model consists of 3 metabolism-related genes—carbonic anhydrase 12, acyl-CoA synthetase long-chain family member 3, and synaptojanin 2— that the researchers said could potentially be used as biomarkers and treatment targets in the disease.

The study suggests blood pressure and cholesterol medications may be appropriate for some younger patients in order to prevent renal complications.

Citing outbreaks of Clostridioides difficile infection in both America and Europe, the researchers emphasized the need for more effective treatments.

The approvals were announced by Bristol Myers Squibb (BMS), maker of the 2 immunotherapy treatments approved for 1 combination: nivolumab (Opdivo), the first approved PD-1 immune checkpoint inhibitor, and ipilimumab (Yervoy), which activates the immune system by targeting CTLA-4.

Real-world patients with moderate to severe plaque psoriasis who had experienced prior biologic failure demonstrated significant improvement and an adequate safety profile with risankizumab treatment.

Using a 6-month lagged CD4/CD8 ratio, researchers found a ratio of 0.30 was associated with a 24% increased risk of any incident cancer among people living with HIV, compared with a ratio of 0.80.

Findings of this study showed arterial stiffness is associated with a higher risk of diabetes onset compared with hypertension.

US adults who survived a COVID-19 infection are more likely than individuals who were not infected with COVID-19 to develop incident conditions attributable to the virus.

Investigators in Spain evaluated symptoms and comorbidities associated with eosinophilic esophagitis.

The researchers found that extramedullary disease at diagnosis was significantly more common in patients with bone marrow fibrosis.

A recent study found positive associations between the organic matter component of particulate matter and disease aggravation in amyotrophic lateral sclerosis (ALS).

Data to be presented next week during the American Society of Clinical Oncology Annual Meeting show that for every 10% increase in public welfare spending, there was a 4.55% narrowing of the 5-year overall survival (OS) disparity between Black and White patients with cancer.

As biosimilar competition heats up in the United States, payers have more tools at their disposal to manage these agents.

A letter from the American College of Rheumatology (ACR) called for drug pricing reforms, deeming them necessary to ensure the health of patients and sustainability of health care systems.

A small study aimed to increase the likelihood of detecting minor neurological symptoms of spinal muscular atrophy via a combination of tests specifically suited to newborns.

Jessica Brooks, MPM, president and chief executive officer, Pittsburgh Business Group on Health, spoke on the core themes of her keynote address related to diversity, equity, and inclusion at the 2022 Greater Philadelphia Business Coalition on Health annual conference.

A retrospective study found that patients with chronic obstructive pulmonary disease (COPD) had stiffer arteries compared with patients without COPD.

Results of a cross-sectional study showed former smokers eligible for lung cancer screening should be asked about recent tobacco use and exposure, while counseling about the harms of these 2 risk factors is warranted.

The governor of Oklahoma signs the nation's most restrictive abortion ban; vaccination against COVID-19 may not prevent long COVID-19; West Virginia reaches tentative settlement with opioid manufacturers.

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

In 2018, annual health care expenditures attributable to current e-cigarette use totaled $15.1 billion or $2024 per person, according to researchers.

Pediatric and adult patients reporting more severe disease courses of atopic dermatitis had a greater risk of select cancers, particularly lymphoma.

A recent study found that patient assessments of symptoms are fit for purpose and can be used by adolescents with alopecia areata in clinical trials and practice.

Thanks to flexibilities provided by the American Rescue Plan, 4 states announced Wednesday they will expand Medicaid coverage to 12 months postpartum, joining others who have already adopted similar measures.

The findings highlight the significant financial burden of sickle cell disease.

Mucosal-associated invariant T (MAIT) cell count was associated with risk of hospitalization in patients with chronic obstructive pulmonary disease (COPD) independent of forced expiratory volume during a 3-year follow-up.

Sharon Phares, PhD, MPH, chief scientific officer of the National Pharmaceutical Council, describes the lasting equity concerns regarding the use of health technology assessments (HTAs) for women.

Research as we know it today, done in isolation and seemingly protected from real-world evidence (RWE), may one day soon be the exception vs the norm, as our ability to amass and extract insights from RWE grows. It’s time that researchers and other industry stakeholders acknowledge the power of using different data sources in a complementary manner to tackle some of health care’s most difficult problems.

Steven Yeh, MD, professor of ophthalmology at the Truhlsen Eye Institute at the University of Nebraska Medical Center, talks about what he sees in the future of suprachoroidal administration and other unmet needs in ophthalmology.