Clinical

The European Medicines Agency (EMA) has accepted a Marketing Authorization Application (MAA) for odronextamab for relapsed/refractory (R/R) follicular lymphoma (FL) or R/R diffuse large B-cell lymphoma (DLBCL) following disease progression after at least 2 prior lines of systemic therapy.

Researchers found that patients with chronic obstructive pulmonary disorder (COPD) with higher Systemic Immune-Inflammation Index (SII) levels have a greater risk of all-cause mortality.

Even patients with diffuse large B-cell lymphoma who are eligible for chimeric antigen receptor (CAR) T-cell therapy face multiple barriers to care and need assistance.

The targeted therapy already has indications in acute myeloid leukemia.

A small study suggests the use of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in patients with mantle cell lymphoma (MCL) with secondary central nervous system (CNS) involvement is safe and effective.

The researchers found that methods of physical activity data collection and processing for patients with interstitial lung disease (ILD) were difficult to interpret and to compare with other disease states.

Patients with RET fusion-positive advanced or metastatic non–small cell lung cancer had a survival benefit when treated with selpercatinib in the LIBRETTO-431 study.

Stroke of an undetermined cause was associated with acute symptomatic seizures, an effect that was marginally mediated by cerebral microbleeds.

Dr Carney drives a discussion surrounding optimal treatment strategies for schizophrenia.

Panelists provide insight into the standards of care for treating patients diagnosed with schizophrenia.

This study compared autoantigen detection of acetylcholine receptor and muscle-specific kinase, among 3 assays used in suspected cases of myasthenia gravis.

Use of SignalPath will improve efficiency, ease compliance, boost enrollment, and ensure financial success in clinical trials, leaders said in interviews.

New research demonstrated varying trends in early-onset cancer incidence based on race, sex, age, and cancer type.

Researchers found that infections and antibiotic use appear to affect the development of late-onset atopic dermatitis (AD), with respiratory infections having a particularly strong influence.

A panel of experts discuss future opportunities with interchangeable biosimilars from payer and provider perspectives.

Jonathan Kay, MD, and Kimberly C. Chen, DO, MSHLM, discuss clinical and financial concerns related to automatic substitution at the pharmacy for an interchangeable biosimilar from a payer perspective.

The CDC made this recommendation after reviewing relevant literature and noting that complete testing jumped from about only two-thirds of patients to nearly all patients.

Theory-based smoking cessation interventions helped to motivate patients with chronic obstructive pulmonary disease (COPD) who smoke to quit, ultimately improving their quality of life and lung function.

Conversation on the four classic causes of acne as well as pathogenesis.

Introduction of expert panelists and treatment guidelines for patients with acne.

Discussion on shared decision making with patients with later stage refractory metastatic colorectal cancer as well as maximizing a patient's quality of life.

The rare disease can cause burning, stabbing, or shooting pain in patients.

The Panicos are on a mission to change how we think about gout. Why? As a husband-and-wife DO duo, the Panicos each have a unique perspective on gout and how physicians in their respective fields can better collaborate to help patients who live with this systemic disease.

The presence of sex differences in immunological functioning influences hidradenitis suppurativa (HS).

Researchers suggest providers learning more about e-cigarettes and updated, effective cessation methods could help their patients overcome barriers to smoking cessation treatment.

Findings from a retrospective analysis suggest an association between bridging therapy and poorer outcomes among patients with aggressive, relapsed/refractory B-cell non-Hodgkin lymphoma (NHL).

Researchers found that costs were highest for those with hospital-onset clostridioides difficile infection (CDI), lower for those with community onset-health care facility association CDI, and lowest for those with community-associated CDI.

Studies showed the various treatments improved symptoms, but more trials need to be done.

Patients given LNK01001 showed significant improvement in Eczema Area and Severity Index scores over placebo.

New research found that ovarian cancer risk is reduced by salpingectomy just as much as by tubal ligation, contradicting guidelines that suggest otherwise.