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Fifty-one therapies have been approved for rare neurological diseases since the FDA passed the Orphan Drug Act in 1983.

The proportions of children and adolescents living with HIV who have achieved viral suppression after antiretroviral therapy initiation were consistently lower than those of adults.

British study finds higher immune response when mixing Pfizer, AstraZeneca COVID-19 vaccines with Moderna; World Health Organization strongly advises against the use of convalescent plasma to treat COVID-19; disparities in pay by gender among physicians.

Real-world evidence from Japan found ixazomib has an acceptable safety profile in patients with relapsed/refractory multiple myeloma (RRMS).

Opinions on the effectiveness and usefulness of telehealth services varied among clinicians and older patients with chronic kidney disease (CKD), suggesting that new measures and training programs should be put in place to mitigate disparities and accessibility issues.

Patients with psoriasis were found to have a more than 20% increased risk of developing incident venous thromboembolism (VTE) and peripheral vascular disease (PVD), with notable at-risk groups including women and those with concomitant psoriatic arthritis.

A cross-sectional study using data from United Kingdom Biobank found that migraine is gender-dependently associated with physically demanding jobs and shift work.

Patients with SLE had higher levels of Wnt5A if they were experiencing active disease.

Results of a systemic review found evidence potentially supporting the use of smart phone applications among mothers with gestational diabetes.

Funmi Olopade, MD, FACP, professor of medicine and human genetics and founding director of the Center for Clinical Cancer Genetics and Global Health at the University of Chicago Medical Center, previews her keynote address for the San Antonio Breast Cancer Symposium (SABCS).

Aaron Lee, MD, an associate professor of ophthalmology at the University of Washington, explains why raising the standard of medical knowledge of artificial intelligence (AI) in ophthalmology is important.

Early data suggest the Omicron variant may cause less severe cases of COVID-19; a new JAMA study finds the average young adult overweight; spotlighting vaccine discrimination in Africa.

Peter Dicpinigaitis, MD, professor of medicine at the Albert Einstein College of Medicine and director of the Montefiore Cough Center, discusses what he and others have seen during the pandemic in patients with chronic cough who had COVID-19.

Although advancements in cancer have been many, disease relapse is still a hurdle for many types of tumors and malignancies, and there is an urgent need to overcome tumor resistance.

A new case report highlights a patient who presented with seizure-like symptoms but was later diagnosed with the rare lysosomal storage disorder.

Interstitial lung disease (ILD), created by inflammation that leads to scarring of the lungs, causes shortness of breath, dry cough, and fatigue; data show it doubles mortality risk in rheumatoid arthritis (RA).

Specifically, patients with nonalcoholic fatty liver disease (NAFLD) have a higher risk of developing heart failure (HF) with preserved ejection fraction, according to new research.

Setting up a palliative care consultation program for patients with acute myeloid leukemia (AML) improved some aspects of care.

Hidradenitis suppurativa, which is linked with microbial dysbiosis and immune dysregulation, is defined by recurrent nodules, tunnels and scarring, primarily in skin folds; the review found a multitude of antimicrobial peptides expressed in this skin disease.

People aging with HIV have more drug–drug interactions compared with those without HIV, according to results of an observational study.

Patients with chronic kidney disease (CKD) and elevated levels of parathyroid hormone who are treated with active vitamin D therapy experienced significantly higher risks of hypercalcemia, investigators concluded in a meta-analysis.

Findings from the single-arm, open-label ASCEND-Peds trial suggest olipudase alfa is well-tolerated and may lead to clinically meaningful improvements in patients with acid sphingomyelinase deficiency (ASMD) who do not have neurovisceral manifestations.

Authors from the University of Colorado say factors from skin irritations, to cost, to lack of insurance coverage, to physician barriers have limited uptake of automated insulin delivery systems.

Multidisciplinary care that includes growth hormone treatment should not cease once patients with Prader-Willi syndrome reach adulthood, according to authors of a study on care outcomes.

New data show the prevalence of potential drug-drug interactions varies according to the drug use pattern considered, with people living with HIV using multiple illegal drugs being at the highest risk.

Mild cognitive impairment has been proposed as a marker for the prodromal phase of Parkinson disease (PD), but little is known about its presentation in community-dwelling older adults.

Circulating Interleukin-11 is difficult to detect in healthy individuals, but when it is present in various inflammatory diseases, it has an elevated present in affected tissues, according to a literature review.

Misinformation about flu vaccines must be dealt with immediately, according to Leslie Kantor, PhD, MPH, chair and professor of the Department of Urban-Global Public Health, Rutgers School of Public Health.

Authors of a review published in Hormones outlined the benefits of healthy eating and physical activity to prevent and improve non-alcoholic fatty liver disease.

According to the researchers, the case study suggests that better results are achieved when using cytoreductive treatment and low-dose aspirin.