Study Examines Relapse Risk in GVHD After Allo-HCT Using 2 Therapy Options
December 9th 2021Despite the increase in relapse risk, 2-year survival for patients with graft-versus-host disease (GVHD) who received matched sibling donor (MSD) allogeneic hematopoietic cell transplant (allo-HCT) administered post-transplant cyclophosphamide remained similar compared with patients receiving cyclosporine A with methotrexate prophylactically.
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Study: Heating Climate Can Lead to Higher Risks of Mortality, Hospitalization in Patients With ESRD
December 9th 2021Rising ambient temperatures were found to be associated with higher risks of all-cause mortality and all-cause hospitalization in patients with end-stage renal disease (ESRD), highlighting the some of the health-related consequences of climate change.
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Use of CAR T-Cell Therapy in LBCL Could Come Earlier After ASH 2021
December 9th 2021Some of the most anticipated presentations at the 63rd Annual American Society of Hematology (ASH) Meeting and Exposition involve phase 3 results for chimeric antigen receptor (CAR) T-cell therapy in second-line treatment.
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Pfizer predicts that a fourth dose of a COVID-19 vaccine may be needed to quell the Omicron variant; CMS officials share figures on enrollment for health coverage under the Affordable Care Act (ACA); City of Hope announces acquisition of Cancer Treatment Centers of America.
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Nail Involvement May Reduce Efficacy of Ustekinumab For Psoriasis
December 9th 2021Nail involvement was shown to reduce the effectiveness of ustekinumab in the treatment of moderate to severe psoriasis, whereas secukinumab exhibited overall higher efficacy than ustekinumab and similar response rates regardless of nail involvement.
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FDA Approves First CGP Test as Companion Diagnostic for BRAF Inhibitor Therapies for Melanoma
December 8th 2021The FDA approved FoundationOneCDx as the first companion diagnostic for current and future BRAF inhibitor therapeutics used to treat melanoma, including both monotherapies and combination therapies.
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Antibodies produced by vaccinated people may be less successful at fighting against Omicron compared with other variants; Congressional leaders created a plan to lift the debt limit with only Democratic votes in the Senate, staving off Medicare cuts; cases of depression and anxiety among youths both doubled during the pandemic.
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Novel Heart Failure Rehab Intervention May Hold Economic Value in the Longer Term
December 7th 2021A secondary analysis of economic outcomes–related data from the Rehabilitation Therapy in Older Acute Heart Failure Patients trial attempted to answer if a novel 12-week rehabilitation intervention held cost-effective value.
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Increased Risk of Fracture Found in Children With Atopic Dermatitis
December 7th 2021Children with atopic dermatitis were shown to be at an increased risk of fractures compared with the general population, with systemic use of corticosteroid and antihistamine therapy cited as mediating factors.
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Project Aims to Increase Pharmacists' Role in Addressing SDOH
December 7th 2021On this episode of Managed Care Cast, guests discuss why pharmacists are in a unique position to help address social determinants of health (SDOH) and the importance of incorporating patients’ perspectives into research agendas.
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Investigators Initiate Post-Trastuzumab Trial of GLSI-100 in Patients With Invasive Breast Cancer
December 7th 2021Investigators hope to duplicate promising phase 2b trial results with an experimental peptide vaccine in a population of nearly 500 patients with human epidermal growth factor receptor 2 breast cancer.
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