Motor Function Continues to Improve in Second Year of Risdiplam Treatment for SMA
November 26th 2022Detailing findings from the secondary end points of the FIREFISH trial at 24 months, the researchers found that risdiplam treatment was associated with continued improvements in motor function and the achievement of development motor milestones.
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Melissa O'Connor, PhD, MBA, RN, FGSA, FAAN, endowed professor in community and home health nursing, M. Louise Fitzpatrick School of Nursing, Villanova University, and director, Gerontology Interest Group, addressed barriers related to access, cost, and knowledge impeding technology use in home health.
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Empagliflozin Has Similar Efficacy Across Subgroups, More Data Needed in CKD: Dr Jennifer Green
November 26th 2022Data on empagliflozin in chronic kidney disease (CKD) showed the drug had similar efficacy across subgroups, but more data is needed to really understand the benefit of the drug in CKD, said Jennifer Green, MD, professor of medicine at Duke University School of Medicine, member of Duke Clinical Research Institute, and EMPA-KIDNEY collaborator.
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Driving Biosimilar Uptake in Rheumatology, Biosimilar-to-Biosimilar Switching: ACR Abstracts
November 26th 2022Abstracts show that institutions can make internal changes to drive the use of biosimilars and that successful biosimilar-to-biosimilar switching is based on patient-related factors.
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Dr Kevin Astle: Long-Acting Injectables Are a Game Changer for Adherence
November 26th 2022Now that long-acting injectables are approved, the next big concern is patient access, said Kevin N. Astle, PharmD, BCPS, BCACP, AAHIVP, CDES, assistant professor at the University of South Florida Taneja College of Pharmacy.
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FGFR Inhibitors Show Promise in Cholangiocarcinoma but Face Acquired Resistance
November 25th 2022There are currently 3 FDA-approved therapies to treat cholangiocarcinoma with FGFR2 fusion or rearrangement, but these therapies face the development of resistance. Studies are underway to identify ways to overcome this resistance.
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Study Details Pandemic’s Depressive Effects in Older Adults
November 25th 2022It is well-known that depression generally, as well as the demand for mental health care, surged because of the pandemic, but few studies have identified the percentage of individuals who experienced depression for the first time after the pandemic began, or the percentage of those with a history of depression who saw it return.
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Long-term Pioglitazone Use May Reduce Risk of Parkinson Disease in Patients With Diabetes
November 25th 2022Findings of a meta-analysis show that pioglitazone use with a dose duration greater than 438 days was associated with a significantly reduced risk of Parkinson disease in patients with diabetes.
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Liz Lightstone, MBBS, PhD, FRCP, professor of renal medicine for the Faculty of Medicine, Imperial College London, discussed how the potential teratogenic effects of novel therapies being investigated for lupus nephritis can impede clinical trial recruitment for women of childbearing age.
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T1D Index Will Be Updated Annually, JDRF’s Tom Robinson Explains
November 24th 2022Updating the Type 1 Diabetes (T1D) Index each year with the latest data and literature and implementing feedback is important for at least the first few years, said Tom Robinson, vice president of global access at JDRF.
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Dr Jason Ezra Hawkes on Advances in Clinical Research and Gaps in Knowledge for Atopic Dermatitis
November 24th 2022Jason Ezra Hawkes, MD, MS, FAAD, board-certified dermatologist and associate professor of dermatology at the University of California Davis in Sacramento, spoke on how clinical studies in atopic dermatitis (AD) are increasingly investigating topics that remain unknown for disease management, including primary vs secondary failures and AD pathophysiology across different ethnic groups.
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Risk of Subsequent Skin Cancer Seen Among Organ Transplant Recipients
November 24th 2022The study's goal was to clarify possible second and third skin cancer development patterns among organ transplant recipients who developed more than 1 instance of skin cancer and to better characterize this patient population by patient age and transplanted organ type.
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Low-Calorie Ketogenic Diet Improved Body Composition, Gut Microbiota Profile in T2D
November 23rd 2022Different dietary approaches were able to improve the state of health in patients with type 2 diabetes (T2D), with very-low-calorie ketogenic diets demonstrating better results on gut microbiota profile.
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Nirmatrelvir-Ritonavir Shows Safety, Efficacy in Real-world Study of High-risk COVID-19 Patients
November 23rd 2022The retrospective study evaluated outcomes in patients prescribed nirmatrelvir-ritonavir, as well as the management of drug interactions by clinical pharmacists prescribing the regimen.
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Persistent Asthma Associated With Cardiovascular Risk Factor
November 23rd 2022An analysis of data from the Multi-Ethnic Study of Atherosclerosis suggests that adults with asthma may have higher levels of carotid artery plaque, which is associated with greater risk of heart attack or stroke.
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Drops in Serum Phosphate Levels May Help Predict Severe CRS After CAR T
November 23rd 2022A new study has found that a drop in serum inorganic phosphate (iP) was an early predictor of severe cytokine release syndrome (CRS), suggesting that monitoring serum iP levels could help promote safer management of the most common toxicity associated with chimeric antigen receptor (CAR) T-cell therapy.
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