Early Diagnosis Vital to Prevent Impairment From Pediatric EGIDs
January 20th 2023Although it is well studied in adult patients, there is a lack of research on eosinophilic gastrointestinal disorders (EGIDs) among pediatric patients; a recent study aimed to add to the clinical knowledge of EGIDs in younger patients.
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Tucatinib Plus Trastuzumab Approved for RAS Wild-type, HER2+ Unresectable or Metastatic CRC
January 19th 2023The combination of tucatinib and trastuzumab received accelerated approval from the FDA to treat adults with RAS wild-type, HER2-positive unresectable or metastatic colorectal cancer (mCRC) that advances after treatment with specific types of chemotherapy.
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Fetal Outcomes, Maternal Mortality Vary Among Pregnant Women With Different Types of PH
January 19th 2023A small study conducted in China suggests pregnant women with idiopathic pulmonary arterial hypertension (iPAH) are at higher risk of maternal mortality compared with women with certain other types of pulmonary hypertension (PH).
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Axi-cel Shows Improved Quality-Adjusted Survival Versus Standard of Care in LBCL
January 19th 2023A Q-TWiST analysis of ZUMA-7 trial data suggests that axicabtagene ciloleucel (axi-cel) in the second line is beneficial to quality-adjusted survival and is a viable option for patients with relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy.
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Interstitial Lung Abnormalities Impact OS in NSCLC Patients Receiving CRT, Adjuvant Durvalumab
January 19th 2023Pretreatment interstitial lung abnormalities were associated with worse overall and cause-specific survival in Japanese patients receiving chemoradiotherapy followed by adjuvant durvalumab for locally advanced non–small-cell lung cancer.
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Screening for SMA in Newborns Alleviates Functional Burden, Associated Comorbidities
January 17th 2023A study found that screening for spinal muscular atrophy (SMA) in newborns paired with early access to disease-modifying therapies was effective in alleviating the burden and comorbidities of the disease.
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The reality of a sickle cell disease cure brings fear, optimism, and questions to patients’ lives; veterans who are in suicidal crisis can receive free emergency care at any Department of Veterans Affairs or private facility; Pfizer to increase access to progressive treatments through sale of drugs at non-profit prices to poor countries.
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No difference in treatment efficacy was observed between intranasal mometasone furoate and saline for the management of sleep-disordered breathing (SDB) symptoms in children, with findings indicating that almost one-half of children with SDB could be initially managed in the primary care setting.
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Paxlovid May Reduce Already Low Risk of COVID-19 Hospitalization, Death Among Vaccinated Patients
January 17th 2023Patients who received nirmatrelvir plus ritonavir (Paxlovid) had lower risk of both hospitalization within 14 days and death within 28 days compared with patients who did not receive the treatment.
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Adherence to Postop Treatment May Indicate Early Recurrence of CRSwNP
January 17th 2023The utility of and adherence to follow-up exams for potential recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) was investigated among 60 patients who had undergone functional endoscopic sinus surgery.
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4-Dose COVID-19 Vaccine Less Effective Beyond 90 Days
January 16th 2023A new study has found that vaccine effectiveness against infection after 4 doses of the COVID-19 vaccine disappeared after 90 days for Omicron variants BA.2, BA.2.12.1, BA.4, and BA.5, although it remained effective against hospitalizations.
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