Panelists discuss how AML treatment has entered an exciting era of personalized medicine with increasing oral options and targeted therapies, while identifying immunotherapy as a major unmet need and expressing optimism about patients achieving long-term survival on current regimens.
Patients with AML can approach their diagnosis with greater hope than ever before, as the treatment landscape has transformed dramatically over the past decade with continued improvements in both survival and quality of life. The shift toward personalized medicine based on individual genetic profiles, combined with the development of effective oral treatment options, means that patients today have access to more tailored and convenient treatment approaches than previous generations. Health care teams emphasize the importance of receiving care at experienced centers with comprehensive support services, advanced genetic testing capabilities, and expertise in managing the complex interactions between new targeted therapies.
The distinction between treatment approaches for younger and older patients continues to evolve, with younger patients benefiting from optimized upfront therapies that may reduce the need for bone marrow transplantation, while older patients gain access to life-extending treatments that prioritize quality of life and reduce hospitalization requirements. Patients across all age groups benefit from the increasing availability of targeted therapies that work specifically against their cancer’s genetic characteristics, moving away from one-size-fits-all chemotherapy toward precision medicine approaches that maximize effectiveness while minimizing unnecessary toxicity.
Looking toward the future, patients can anticipate continued advances in immunotherapy approaches, which represent the next frontier in AML treatment development, though current immunotherapy options remain limited compared to other cancer types. The success of oral combination regimens points toward even more sophisticated treatment approaches that allow patients to maintain independence and quality of life while receiving highly effective antileukemia therapy. Health care providers remain optimistic about continued improvements in patient outcomes, with many patients already experiencing years of disease control on treatments that were unavailable just a few years ago, demonstrating that scientific advances continue to translate into meaningful benefits for patients facing this challenging diagnosis.
Managed Care Reflections: A Q&A With A. Mark Fendrick, MD, and Michael E. Chernew, PhD
December 2nd 2025To mark the 30th anniversary of The American Journal of Managed Care (AJMC), each issue in 2025 includes a special feature: reflections from a thought leader on what has changed—and what has not—over the past 3 decades and what’s next for managed care. The December issue features a conversation with AJMC Co–Editors in Chief A. Mark Fendrick, MD, director of the Center for Value-Based Insurance Design and a professor at the University of Michigan in Ann Arbor; and Michael E. Chernew, PhD, the Leonard D. Schaeffer Professor of Health Care Policy and the director of the Healthcare Markets and Regulation Lab at Harvard Medical School in Boston, Massachusetts.
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