Balancing Timing of ASCT: Insights on Delayed Transplantation and Long-Term Treatment Outcomes
June 27th 2025Panelists discuss how autologous stem cell transplant (ASCT) deferral should be approached cautiously with concrete medical reasons, as transplant continues to provide superior progression-free survival and potentially curative outcomes for a subset of patients.
Tailoring Maintenance Therapy by Patient Risk: Lenalidomide Alone vs Combination Approaches
June 27th 2025Panelists discuss how maintenance therapy should be tailored based on risk profiles, with standard-risk patients receiving single-agent lenalidomide while high-risk patients may benefit from combination maintenance strategies to achieve more durable responses.
The Role of MRD Status in Post-ASCT Treatment Decisions and Clinical Integration
June 20th 2025Panelists discuss how minimal residual disease (MRD) status can guide post-transplant treatment decisions, particularly for high-risk patients who don’t achieve MRD negativity and patients considering discontinuation of long-term maintenance therapy.
Evaluating First-Line Treatment Options: Quadruplet vs Triplet Regimens and NCCN Guidelines
June 20th 2025Panelists discuss how quadruplet regimens show improved efficacy over triplet regimens without significantly increased safety concerns, with anti-CD38 antibodies being well tolerated and NCCN guidelines now recommending 4-drug regimens for transplant-eligible patients.
Treatment Approaches and Goals: Transplant-Eligible vs. Transplant-Ineligible Patients
June 13th 2025Panelists discuss how treatment strategies differ between transplant-eligible and transplant-ineligible multiple myeloma patients, with transplant eligibility determined by functional status rather than age alone, and how quadruple therapy regimens are increasingly used for transplant-eligible patients to achieve deep, durable responses.