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Evolution of Endocrine Therapies in ER+/HER2– Metastatic Breast Cancer
Experts discuss evolving strategies in ER+/HER2– metastatic breast cancer treatment, combining endocrine and targeted therapies, and leveraging specific mutations for optimal patient outcomes.
EP: 1.Evolution of Endocrine Therapies in ER+/HER2– Metastatic Breast Cancer
EP: 2.Efficacy and Safety of Oral SERDs and Other Endocrine Therapies in ER+/HER2- Metastatic Breast Cancer
EP: 3.Elacestrant Usage in ER+/HER2- Metastatic Breast Cancer: Clinical Guidelines and Patient Profiles
EP: 4.ESR1 Mutation Testing and Precision Medicine in Patients With ER+/HER2- Metastatic Breast Cancer
EP: 5.Elacestrant in Later-Line Treatment of ER+/HER2– Metastatic Breast Cancer
EP: 6.Elacestrant: Treatment Considerations, Including Dosing and Compliance
EP: 7.Elacestrant: Adverse Effects and Their Management, and Impact of Treatment on Quality of Life
EP: 8.Emerging Agents and Clinical Perspectives in ER+/HER2- Metastatic Breast Cancer
EP: 9.Overview of ESR1 Mutations in ER+/HER2- Metastatic Breast Cancer
EP: 10.Best Practices for ESR1 Mutation Testing in Patients With Breast Cancer
EP: 11.The Role of Oral SERDs in ER+/HER2- Metastatic Breast Cancer
EP: 12.Oral SERDs in Development for ER+/HER2- Metastatic Breast Cancer
EP: 13.Research Landscape: Endocrine Therapies for ER+/HER2- Metastatic Breast Cancer
This is a video synopsis/summary of a Peer Exchange featuring Mabel Mardones, MD; Rena Callahan, MD; William Gradishar, MD; and Gregory Vidal, MD, PhD.
Mardones leads a panel discussion on advances in therapy for estrogen receptor–positive (ER+)/HER2-negative (HER2–) metastatic breast cancer. Gradishar underscores the evolving treatment landscape, emphasizing the combination of endocrine and targeted therapies while considering specific mutations.
Vidal focuses on selective estrogen receptor degraders (SERDs), explaining their distinct mechanism compared with other anti-estrogen therapies. SERDs bind to receptors, facilitating their degradation and offering a unique approach. Vidal also mentions combination therapies with CDK4/6 inhibitors as part of targeted therapy strategies.
This expert dialogue provides crucial insights into the latest developments, particularly the role of oral SERDs, guiding clinicians in the dynamic field of metastatic breast cancer treatment.
Video synopsis is AI-generated and reviewed by AJMC® editorial staff.
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