Refining Serological Weight Scoring to Increase RA Classification Specificity
January 25th 2022After analyzing past studies and classification criteria, authors found multiple factors that could be implemented into the current rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) tests for a more specific rheumatoid arthritis (RA) classification.
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FDA significantly restricts the use of 2 COVID-19 monoclonal antibody treatments ineffective against the Omicron variant; an expert panel advises the Israeli government to offer a fourth COVID-19 vaccine dose to adults; there was a substantial increase in visits for mental health and substance abuse among physicians with no prior history during the pandemic.
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MRD Continues to Reliably Predict Disease Progression in CRC
January 24th 2022In this poster presented at the 2022 ASCO Gastrointestinal Cancers Symposium, minimal residual disease (MRD) status as detected by postsurgery plasma cell-free DNA continued its strong track record of being a reliable predictor of disease progression in colorectal cancer (CRC).
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Gender Differences for Health-Related QOL Detected Among Patients With Advanced Kidney Disease
January 24th 2022Although men and women with advanced kidney disease experienced physical and mental declines in health-related quality of life (QOL), men’s declines occurred at a significantly faster rate, researchers concluded.
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Dr David R. Stukus on Eosinophilic Esophagitis Guidelines and the Pattern of Disease
January 24th 2022David R. Stukus, MD, FACAAI, of Nationwide Children's Hospital and The Ohio State University College of Medicine, and a board member of the American College of Allergy, Asthma & Immunology, discusses guidelines for eosinophilic esophagitis, as well as some disease patterns that may occur.
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Genomic Profiling Uncovers Mutations More Enriched in Early-Onset Colorectal Cancer
January 24th 2022Findings presented at the 2022 ASCO Gastrointestinal Cancers Symposium showed no significant differences in tissue and plasma genomic profiles of patients with early-onset and late-onset colorectal cancer, but a greater enrichment of the BRCA1 and PTEN mutations were noted in the tissue of those with early-onset disease.
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The CDC is working to change its definition of being fully vaccinated against COVID-19; a study finds that men who tested positive for COVID-19 showed a short-term decline in fertility; a nonprofit group of scientists seeks to optimize the clinical trial process and reduce cost.
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Endoscopic Sinus Surgery With Medical Therapy Effective for Chronic Rhinosinusitis With Nasal Polyps
January 22nd 2022Patients with chronic rhinosinusitis with nasal polyps were found to benefit more from the combination of endoscopic sinus surgery plus medical therapy vs medical therapy alone, although the minimal clinically important difference was not met.
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Severe Daytime Sleepiness Linked With Parkinsonian-Like Symptoms, Study Finds
January 22nd 2022The severity of excessive daytime sleepiness correlated with the prevalence of Parkinsonian-like symptoms in adults aged 50 to 64, but further research is needed to determine the mechanisms behind the findings.
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Large, Retrospective Study Offers Insight Into AGEP Disease Course, Complications
January 22nd 2022Among the most notable findings were that acute generalized exanthematous pustulosis is typically triggered by antimicrobial agents and may be associated with complications of the liver or kidney for some patients.
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Dr Edward W. Cowen Discusses Pathophysiology, Treatment of Pustular Psoriasis
January 22nd 2022Edward W. Cowen, MD, MHSc, senior clinician and acting branch chief, Dermatology Branch, National Institutes of Health, speaks on cytokines involved in the pathophysiology in pustular psoriasis and off-label therapy use.
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Report Examines Extent of Disruption of Health Services for Patients With PD, Dementia in Ontario
January 21st 2022Researchers said they wanted to take a broad look at the level and scope of the disruption for those with Parkinson disease and dementia still living at home and compare the findings to before the pandemic.
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Patents Filed a Decade Post Originator Approval Account for Most Biosimilar Patent Lawsuits
January 21st 2022Researchers have found that most US patent infringement cases against biosimilar manufacturers cover patents filed over a decade after the originator product's FDA approval, leading to limits on competition among biologic drugs.
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