Three CAR T-Cell Trials, 2 Outcomes, for Second-line LBCL Therapy
August 4th 2022Both the ZUMA-7 trial for axicabtagene ciloleucel—approved for second-line treatment earlier this year—and the TRANSFORM trial for lisocabtagene maraleucel showed significant improvement over standard of care for large B cell lymphoma (LBCL), while the BELINDA trial for tisagenlecleucel did not.
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Phase 3 Study: Zanubrutinib Improves PFS Over Chemoimmunotherapy in Untreated CLL, SLL
August 4th 2022The findings, coming from the phase 3 SEQUOIA study, found that the next-generation, selective Bruton tyrosine kinase inhibitor had superior efficacy versus chemoimmunotherapy and demonstrated an acceptable safety profile among 600 older patients with comorbidities.
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NGF-Based MRD Assessment Demonstrates Potential to Predict MM Disease Progression
August 4th 2022Previous studies have produced heterogeneous results on next-generation flow (NGF)-based minimal residual disease (MRD) detection, despite improvements to the method’s reproducibility and sensitivity, prompting the present authors to investigate its clinical utility.
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President Joe Biden signed an executive order to help people travel between states for an abortion; Eli Lilly was ordered to pay $61 million after allegedly underpaying the Medicaid drug rebate program; CVS plans to acquire or take a stake in a primary care industry by the end of 2022.
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Federal Holidays, Daylight Savings Have Effect on Sleep Duration, Consistency
August 4th 2022A retrospective observational study found that many US federal holidays and holiday eves were associated with changes in sleep duration, decreases in sleep consistency, and later sleep onset and offset.
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For Early-Stage cHL Survivors, CVD Has Surpassed Neoplasms as Leading Cause of Death
August 3rd 2022Cardiovascular disease (CVD) has, over time, becoming the leading cause of death for patients with early-stage classic Hodgkin lymphoma (cHL), surpassing the risk of death from cHL and other cancers.
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Cardiologists Must “Get Into the Game” With Novel Agents in Patients With Diabetes
August 3rd 2022During the 2022 Congress of the American Society for Preventive Cardiology (ASPC), held in Louisville, Kentucky, Erin D. Michos, MD, MHS, of Johns Hopkins, and Pam R. Taub, MD, of UC San Diego Health, discussed how treatment of diabetes requires going beyond glucose-lowering therapies and including newer medications that offer cardiovascular benefits.
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Tools Physical Therapists Can Use to Create Plans for Safe Aging in Place
August 3rd 2022Comprehensive geriatric assessments are designed to keep frail older adults healthy and out of hospitals and nursing homes; a recent article described the the components that make up an assessment and how they can apply to a physiotherapy evaluation.
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Data Support Safety, Effectiveness of Biosimilar-to-Biosimilar Switching
August 3rd 2022Although there is a paucity of data of switching among biosimilars of the same reference product, the few studies published support the safety and effectiveness of transitioning patients from one biosimilar to another.
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Asian Patients With Psoriasis Receive Shortest Visits With Dermatologists
August 3rd 2022Dermatologists spend less time face-to-face with Asian patients with psoriasis compared with patients of other races and ethnicities, despite Asian patients frequently experiencing more severe cases of psoriasis.
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Kansas voters rejected an anti-abortion measure while the Department of Justice sued Idaho to protect abortion access; the US uninsured rate hit a record low of 8% at the start of 2022; the Senate passed an expansion of veteran health care, sending it to President Biden’s desk.
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Dr Courtney Crim Outlines Creating Personalized Treatment Regimens for COPD
August 3rd 2022There are various treatments on the market for patients with chronic obstructive pulmonary disease (COPD), all with their own pros and cons to be considered as part of a personalized treatment regimen.
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Incidence, Mortality, Costs Increased Among Medicaid Patients With NVHAP
August 3rd 2022A recent study calculated the incidence and mortality rates for patients with Medicaid coverage who had nonventilator hospital-acquired pneumonia (NVHAP) and found possible associations between greater health care costs and NVHAP diagnosis.
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Risk of Keratinocyte Carcinoma Increases With Pediatric Solid Organ Transplant
August 2nd 2022This new study investigated keratinocyte carcinoma mortality and morbidity rates following pediatric solid organ transplant. Little is known on these associations in pediatric patients; more is known of these outcomes among adult patients.
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