BRVO, CRVO Need More Effective Long-term Therapies
February 12th 2023While the current therapies are effective for treating branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO), they are inadequate for long-term treatment in clinical practice, according to an analysis of real-world data.
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High-Dose Aflibercept in Wet AMD and DME Provides Therapeutic Benefits, No New Safety Signals
February 12th 2023Two studies looking at a higher dose of aflibercept found that an 8-mg dose can be maintained at longer dosing intervals with similar benefits and no additional safety signals compared with the 2-mg dose.
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Dr Mary Cushman: Has an "Awakening of Consciousness" Improved Certain Treatment Disparities?
February 11th 2023Mary Cushman, MD, professor of medicine at the University of Vermont, and director of the thrombosis and hemostasis program at the University of Vermont Medical Center, talks about racial disparities in pulmonary embolism treatment.
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Long-term Antidepressant Drug Use Linked With Risk of Epilepsy
February 11th 2023Individuals exposed to antidepressant drugs for longer than 365 days had an increased risk of epilepsy, particularly those given escitalopram, venlafaxine, and mirtazapine, according to a recent study conducted in Taiwan.
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Family-Centered Interventions Improve Health Outcomes in Children, Adolescents With T1D
February 11th 2023Interventions in 9 studies were linked with varying effects on glycated hemoglobin, type 1 diabetes (T1D) management adherence, self-management behaviors, and parent-child teamwork in T1D management.
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Genetic Screening Could Have Promise for Reducing Infant Deaths
February 11th 2023An analysis of 112 infant deaths found that the contribution of genetic diseases to mortality was higher than previously known, and that treatments are available for 30% of the genetic diseases uncovered by the study.
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Despite High False-Positive Rate of FIT, Patients With Hemophilia Have High CRC Detection Rate
February 11th 2023The researchers underscored the importance of their findings for a wide group of patients with inherited bleeding disorders, as most colorectal cancer (CRC) screening programs across the globe use fecal immunochemical testing (FIT).
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Home OCT: Providing More Personalized, Timely Treatment for Wet AMD
February 11th 2023Home optical coherence tomography (OCT) has shown there is a wide degree of heterogeneity in fluid dynamics and treatment response that may not be clear during regular office visits and scans. Presenters reviewed the latest data in home OCT to manage wet age-related macular degeneration (AMD).
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Mitochondrial Stabilizing Drugs Have Potential to Reverse Vision Loss in Dry AMD
February 10th 2023A review of data on 2 mitochondrial membrane stabilizers—risuteganib and elamipretide—has highlighted the potential to not just slow disease progression but actually reverse vision loss in patients with intermediate dry age-related macular degeneration (AMD).
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CMS Releases Guidance on the Math Behind Part B, Part D Drug Rebates
February 10th 2023The Biden administration released 2 sets of guidance documents for pharmaceutical manufacturers about how it plans to implement the new Medicare Prescription Drug Inflation Rebate Program as required under the Inflation Reduction Act, and said some beneficiaries could see lower coinsurance for some Part B drugs as soon as April 1.
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Dr Kirk Campbell Discusses Mount Sinai’s Educational Research, Clinical Initiatives on Health Equity
February 9th 2023Kirk Campbell, MD, FASN, Vice Chair for Diversity, Equity, and Inclusion in the Department of Medicine at Mount Sinai Health System in New York, spoke on educational initiatives implemented by Mount Sinai to train resident physicians, medical students, and senior faculty on health equity, as well as further research efforts to address disparities.
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Adult Immunization Recommendations Receive Update for 2023
February 9th 2023The Advisory Committee on Immunization Practices released the update to the Recommended Adult Immunization Schedule for all US residents aged 19 years and older, which has been approved by the CDC and medical groups.
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Brexucabtagene Autoleucel Shows High Rate of Durable Response at 3 Years
February 9th 2023Chimeric antigen receptor T-cell therapy brexucabtagene autoleucel showed a rate of complete remission of 71% and a rate of complete remission with incomplete hematologic recovery of 56%, according to 3-year follow-up results.
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Jessica Allegretti, MD, MPH, medical director of the Crohn's and Colitis Center, Brigham and Women's Hospital, discussed how the FDA’s approval of Rebyota for the prevention of recurrent Clostridioides difficile infection (CDI) may promote cost effective management of CDI for patients and health systems.
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While treatment with allogeneic hematopoietic cell transplantation (allo-HCT) showed improved disease-free survival compared with conventional consolidation chemotherapy, the findings suggest there may not be an overall survival (OS) benefit with allo-HCT for patients with intermediate-risk acute myeloid leukemia (AML) during first complete remission.
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Hyaluronic Acid Spacer May Reduce Rectal Dosimetry, GI Toxicity From Prostate Cancer Treatment
February 9th 2023A randomized controlled trial found that the use of a rectal spacer may help mitigate the gastrointestinal (GI) toxicity associated with hypofractionated radiation therapy for prostate cancer.
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China’s angry reaction after spy balloon retrieval rouses drug supply chain anxiety; after allegedly overcharging California’s Medi-Cal program, managed care company Centene will pay millions in a settlement; major drug companies are chasing new pharma deals amidst dropping patent exclusivity.
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