Parkinson Disease

Among caregivers of patients with Parkinson disease experiencing psychosis, only 11% learned about the symptom from a physician, with communication challenges attributed to having to prioritize other issues in a limited appointment time.

Patients with levodopa-responsive and levodopa-resistant tremors exhibit differing preferences on the type of deep brain stimulation administered to control motor function in Parkinson disease.

Visual dysfunction among patients with Parkinson disease was associated with worse cognitive performance after 18 months and a higher risk of developing mild cognitive impairment compared with those with normal vision.

Fungi within the gut microbiome were not found to be a contributing factor to the initiation and progression of Parkinson disease, contrary to prior findings.

An Apple Watch designed to remotely monitor fluctuations of resting tremor and dyskinesia in persons with Parkinson disease was shown to match in-clinic evaluations of these symptoms and capture symptom changes in response to treatment for 94% of participants.

Use of drugs commonly used to treat enlarged prostate was associated with a reduced risk of developing Parkinson disease in men.

A recent survey found that patients experienced relief of certain motor and nonmotor symptoms of Parkinson disease from using cannabis.

Changes in blood pressure, percentage of red blood cells, and serum cholesterol levels were found to occur in patients with Parkinson disease before the onset of motor symptoms, suggesting potential biomarkers for early diagnosis and treatment.

A study on the effects of Mediterranean diets on Parkinson disease found a strong correlation between food intake and disease onset, while also suggesting a possible link between sex and diet results.

Focused ultrasound subthalamotomy was shown to improve motor features among patients with Parkinson disease who present with asymmetric symptom severity.

Defective metabolism of levodopa in the brain was associated with a decline in the drug's efficacy over time and the adverse effect of dyskinesia among patients with Parkinson disease.

A recent study explored how patients with Parkinson disease who suffer from constipation are more likely to have other nonmotor symptoms than patients without constipation.

Patients with newly diagnosed Parkinson disease (PD) who carried mutations in the Parkin gene were found to exhibit worse quality of life, longer disease duration, and an earlier age at disease onset than those with PD who did not carry the mutation.

The top 5 most-read Parkinson disease stories of 2020 on AJMC.com included the latest insights on treatments such as spinal cord stimulation and the role of dietary management, as well as implications of the coronavirus disease 2019 pandemic.

Tomatoes metabolically engineered to be enriched by the antiparkinsonian drug levodopa may provide a novel, cost-effective source of the drug for patients with Parkinson disease.

Among patients with Parkinson disease, a positive history of essential tremor was found to be associated with slower progression of motor and nonmotor symptoms, with no impact observed on survival.

Patients with Parkinson disease were shown to be at greater risk of suicide than matched participants in the general population, according to study findings published last week.

Amid the coronavirus disease 2019 pandemic, patients with Parkinson disease reporting feelings of loneliness were found to experience greater severity of symptoms.

Eli Lilly & Co is set to acquire Prevail Therapeutics Inc for almost $1 billion; Pfizer’s coronavirus disease 2019 vaccine vials found to contain extra doses; a new treatment has been approved for patients with advanced breast cancer.

Researchers review the association between Parkinson disease and dermatologic disorders, as well as implications that this link may have on the pathophysiological mechanisms underlying Parkinson disease.

The effectiveness of telemedicine services among patients with neurological conditions was spotlighted amid the coronavirus disease 2019 (COVID-19) pandemic, particularly how telephone and video consultations have fared in temporarily replacing face-to-face consultations.

Researchers discuss the latest advances in technology-enabled care under development for Parkinson disease, as well as potential challenges to achieve full integration.

Low-frequency transcranial stimulation of the pre-supplementary motor area was found to delay the onset and reduce severity of levodopa-induced dyskinesia in patients with Parkinson disease.

An eye exam paired with artificial intelligence machine learning technology may provide a novel approach to diagnose Parkinson disease in early stages.

A machine learning approach that works to identify mitochondrial impairments, a potential mechanism underlying the pathogenesis of Parkinson disease (PD), accurately distinguished between patients with PD and healthy controls.

Patients with Parkinson disease (PD) who do not experience tremor were found to show improvements in reward learning after taking dopaminergic medication, while those with PD and tremor exhibited no benefit in reinforcement learning.

Individual-level low socioeconomic status (SES) was found to be significantly associated with increased mortality in Korean patients with Parkinson disease, whereas regional-level SES was not.

Researchers discuss the development and potential of stem cell–based therapies in the treatment of Parkinson disease.

A skin test to detect clumping of alpha-synuclein, an abnormal protein suggested to have a central role in the pathogenesis of Parkinson disease, may assist in improving earlier detection of the condition, according to study findings.

Air pollution was found to be significantly associated with an increased risk of hospital admissions for several neurological disorders, including Parkinson disease, Alzheimer disease, and other dementias.