Inflammation

An article published in the journal Gastroenterology & Hepatology highlights recent updates to eosinophilic gastrointestinal disease nomenclature, as well as updates related to diagnosis, pathogenesis, and treatment standards.

The study findings suggest that eosinophilic esophagitis (EoE), like other atopic diseases, may be associated with infections.

The investigators of this new study wanted to more clearly define the patient characteristics of the 2 main types of chronic rhinosinusitis: with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP).

The investigators of a new study evaluated if nasal cytology was a reliable method to identify type 2 inflammation in patients who have chronic rhinosinusitis with nasal polyps (CRSwNP), which could then facilitate patient selection for biological drug utilization via endotypization.

A significant uptick in chronic rhinosinusitis with nasal polyps (CRSwNP) among patients with comorbid asthma has been seen in the country over the past decade.

The findings follow recent data suggesting that esophageal dysmotility may be associated with eosinophilic esophagitis (EoE), which often presents with dysphagia.

The study, say researchers, adds insight into risk factors predictive of response to dietary intervention for eosinophilic esophagitis (EoE), as dietary failure occurs in up to 30% of patients.

The index for eosinophilic esophagitis (EoE) was crafted based on a literature review by a multidisciplinary team of experts.

The goal of this new study was to gain more information on the disease burden, including costs, of patients living with chronic rhinosinusitis with nasal polyps (CRSwNP).

While the prevalence of eosinophilic esophagitis (EoE) is estimated to be 0.5% in the general population, a recent study found that the prevalence was as high as 16.5% in patients with allergic disease.

A search of the peer-reviewed literature turned up inconsistent findings on the effectiveness of corticosteroid irrigation for the treatment of chronic rhinosinusitis (CRS) with nasal polyps.

The effect of dupilumab was investigated among patients with severe and uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).

Despite extensive study, eosinophilic chronic rhinosinusitis (ECRS) remains a significant health problem with few effective treatments, so this study compared periostin levels among those who did and did not have ECRS to assess its potential as a disease biomarker.

Researchers investigated potential risk factors for the higher occurrence of asthma among individuals who have chronic rhinosinusitis with nasal polyps (CRSwNP).

Overall, 65% of patients went into remission throughout the observation period, with those with concurrent eczema and pollen food syndrome (PFS) having favorable responses.

With a high recurrence rate following surgery to treat chronic sinusitis with nasal polyps, authors set out to investigate the effectiveness and safety of endoscopic sinus surgery (ESS) in a pediatric patient population.

Headaches, injection site reactions, and pharyngitis were the most common adverse events associated with the biologic therapies dupilumab, omalizumab, mepolizumab, and reslizumab in the treatment of chronic rhinosinusitis (CRS) with nasal polyps.

It is already known that patients with eosinophilic esophagitis have higher levels of immunoglobulin G4, and this study examined the relationship to specific foods and aeroallergens.

Although allergic and atopic disease is well studied and researched overall, the researchers said there is a critical lack of knowledge about these conditions, including eosinophilic esophagitis, asthma, and atopic dermatitis, in diverse racial and ethnic groups.

Risk factors as predictors of asthma prevalence among a cohort of patients living with chronic rhinosinusitis (CRS), as they related to age, were evaluated by clinical investigators from the College of Medicine at Korea University.

Using systemic corticosteroids (SCS) to treat chronic rhinosinusitis with nasal polyps (CRSwNP) has been linked to adverse outcomes among patients, prompting these study investigators to compare their health care resource utilization with that of patients who have CRSwNP but don’t use SCS.

A recent study attempted to determine the prevalence of eosinophilic esophagitis (EoE) in a group of patients allergic to milk or egg and undergoing oral immunotherapy (OIT) to those foods, as well as describe its management and treatment pathway.

The researchers compiled data from studies of lirentelimab, mepolizumab, reslizumab, and benralizumab, highlighting the difficulties in finding an effective approach with eosinophil-targeted treatments for eosinophilic esophagitis (EoE).

With evidence lacking on the role of inflammation in nasal polyposis (NP), this study investigated the role of 2 potential biomarkers in the nasal secretions of patients who have NP concomitant with aspirin-exacerbated respiratory disease.

In this study, researchers reaffirmed the safety and efficacy of using budesonide to treat eosinophilic esophagitis (EoE).

This study investigated combination treatment of antibiotics plus corticosteroids among persons with aspirin-exacerbated respiratory disease, a subtype of chronic rhinosinusitis with nasal polyposis (CRSwNP).

Despite intranasal corticosteroid (INCs) being a treatment mainstay for chronic rhinosinusitis with nasal polyps, there are ongoing high rates of nonadherence, which can affect treatment efficacy, according to this study’s authors.

A study of adult patients with eosinophilic esophagitis in remission showed that those who were followed more closely in the maintenance phase of treatment had fewer strictures and had their disease activity found earlier.

European patients with eosinophilic esophagitis (EoE) had an improved diagnosis process and a faster diagnosis as new clinical practice guidelines were published over time, according to the results of a recent study.

This study investigated the potential for postoperative recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) as measured against B7-H4 expression.