Jared Kaltwasser

Patients with cold agglutinin disease faced a 4.5-times greater risk of death during winter months, new data show.

A survey of patients and health care providers found both groups favor at-home administration of biologics when possible.

Experts warn, however, that human papillomavirus (HPV) vaccinations missed because of the COVID-19 pandemic could stymie this progress.

All patients said insulin pump therapy helped their diabetes management related to exercise.

The study found associations between miRNA-499 polymorphism and autoimmune disease risk in Caucasian and Asian populations, including a significantly increased risk of rheumatoid arthritis and systemic lupus erythematosus.

The drug yielded partial responses in 2 of 15 patients in this single-arm, phase 2 study.

Data from this new study suggest melanoma cases rose at a slower rate in lower-income countries, but the authors say that may be due to differences in case documentation.

This new research may help investigators prevent skin lesions.

More experienced dermatopathologists were less likely to see overdiagnosis as a significant public health problem, a new survey showed.

The study highlights differences between patients with systemic lupus erythematosus (SLE) and healthy controls, potentially shedding light on the disease’s underlying mechanisms.

A subsequent analysis suggested, however, that segmentectomy was preferable to lobectomy in many cases.

Investigators found quality of life (QOL) effects may be tied to patients’ perceptions of cognitive impairment, rather than objective measurements of impairment from systemic lupus erythematosus (SLE).

Investigators found 6 genes associated with cancer-associated fibroblasts that appear to correlate with response to anti-PD-1 immunotherapy.

In patients with liver involvement, intrahepatic cholangiocarcinoma was a common diagnosis among some patients with cancer of unknown primary (CUP).

Although classic methods of risk stratification still hold value, the authors said genetic analysis holds significant promise.

The study showed that introducing the TLR7 variant in an animal model led to the development of autoimmune symptoms and potential development of systemic lupus erythematosus (SLE).

Among a cohort of 88 patients with acute myeloid leukemia who received hypomethylating agents with venetoclax prior to allogeneic hematopoietic cell transplant, 85% had achieved morphologic complete response at 100 days.

A new commentary suggests new pathways might lead to a major shift in the treatment of pulmonary arterial hypertension (PAH).

The finding is important because evidence suggests it is becoming more common for patients to receive care from a general practitioner for skin cancer, versus a surgeon or dermatologist.

Recent studies suggest patients with Parkinson disease (PD) suffer from tooth grinding and related pain at higher rates than healthy controls.

Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.

Inflammatory microenvironments appear to enhance melanoma cells’ ability to control T-cell responses.

Patients with reduced DNA mismatch repair protein expression were more likely to respond to immune checkpoint inhibitors (ICIs), although this study had a small sample size.

A new review article shows positive trends in survival, as scientists better understand the different types and symptoms of pulmonary arterial hypertension (PAH).

Patient education is an important step toward improving outcomes for racial and ethnic groups disproportionately affected by lupus, but a new report suggests payers and physicians also have more to learn about the problem.

A new review article highlights a number of roles for B1 cells, including antibody secretion and the stimulation of CD4+ cells.

Investigators said these differences might help explain why some patients have better outcomes than others with combination immune checkpoint blockades.

Expression of the chemokine receptor was linked with better overall survival.

The research could pave the way for therapies that target enhancers of disease-related genes.

It is not yet clear what impact proactive screening might have on health care costs and survival outcomes.