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Next Steps: Post-Frontline Therapies and Resistance in ALK+ NSCLC
Panelists discuss how alectinib use in the adjuvant setting might shift sequencing strategies in metastatic ALK+ non–small cell lung cancer (NSCLC) and how resistance mutations influence post-frontline therapy selection.
EP: 1.The Evolution of ALK+ NSCLC Care
EP: 2.Lorlatinib in Focus: Survival, Brain Metastases, and Beyond
EP: 3.Choosing Wisely: Insights from an MAIC and eXalt3
EP: 4.Applying Trial Data to Real-World Practice in ALK+ NSCLC
EP: 5.Key Differences Among ALK Inhibitors
EP: 6.Navigating ALK Inhibitor Toxicities
EP: 7.Lorlatinib’s Unique Challenges: Managing Cognitive and Metabolic AEs
EP: 8.Long-Term Success: Educating and Supporting Patients on ALK Inhibitors
EP: 9.Equitable Access to Molecular Testing and Treatment Prioritization
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EP: 10.Next Steps: Post-Frontline Therapies and Resistance in ALK+ NSCLC
Sequencing Strategies and Resistance Management
Key Themes:
- Impact of adjuvant alectinib use (ALINA) on sequencing strategies
- Selection of post-frontline therapies after ALK inhibitor progression
- Role of resistance mutations in therapy selection
- Emerging data on NVL-655 (from ESMO 2024)
Notable Insights:
- Dr Dietrich explored how adjuvant ALK inhibitor exposure might influence frontline metastatic therapy selection
Dr Lovly discussed strategies for selecting therapies after progression, including considerations of resistance mutations and data on NVL-655
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