Monitoring Immunotherapy Toxicities in CSCC and BCC

EP: 1.Prevalence of Cutaneous Squamous Cell Carcinoma (CSCC) & Basal Cell Carcinoma (BCC)

EP: 2.Immunotherapy Landscape in cSCC and BCC

EP: 3.Immunotherapy and Radiation Therapy in cSCC and BCC

EP: 4.Immunotherapy Barriers: Multidisciplinary Approach in cSCC and BCC

EP: 5.Coordination of Care: Interdisciplinary Immunotherapy Challenges in Nonmelanoma Skin Cancers

EP: 6.Multidisciplinary Collaboration: Best Practices for CSCC and BCC Management

EP: 7.Dermatologists and Immunotherapy: Managing Patient Expectations

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EP: 8.Monitoring Immunotherapy Toxicities in CSCC and BCC

EP: 9.Staging Disease and Risk Stratification in CSCC and BCC

EP: 10.Targeted Therapy: Hedgehog Inhibitors in BCC

EP: 11.Socioeconomic Implications of CSCC and BCC

EP: 12.Immunosuppression in CSCC and BCC Treatment

EP: 13.Updates in Therapeutics for Nonmelanoma Skin Cancers

EP: 14.Concluding Thoughts on the Future of CSCC and BCC Care

This is a video synopsis/summary of a Peer Exchange involving Jason Luke, MD, FACP; Christopher Barker, MD; Omid Hamid, MD; Vishal Patel, MD; and Catherine Pisano, MD.

Barker stated that while radiation toxicities can mimic immunotherapy adverse effects, a large analysis did not find radiotherapy increased immune-related adverse event rates when given within 90 days of immunotherapy initiation. Thus, adverse effects likely represent an additive effect of the 2 modalities rather than synergy. He emphasized the importance of continual cross-disciplinary communication to best attribute causality. Patel advised community providers using immunotherapy to have referral networks in place to manage unfamiliar toxicities. Hamid discussed engaging multidisciplinary care early for recurrent or aggressive skin cancers needing complex resection. Pisano described high-risk features that should trigger medical oncology referral, including rapidly enlarging/painful lesions, multiple in-transit metastases, invasion beyond subcutaneous fat, and perineural invasion on microscopy. She explained that subtle signs like skin fixation can sometimes indicate deep invasion on exam when pathology is pending.

Video synopsis is AI-generated and reviewed by AJMC® editorial staff.