Important Clinical Considerations for Patients With Bronchiectasis

EP: 1.Common Symptoms Seen With Bronchiectasis

EP: 2.Examining The Pathophysiology Of Bronchiectasis

EP: 3.Exploring the Impact of Bronchiectasis Exacerbations

EP: 4.Analyzing Treatment-Refractory Patients

EP: 5.Common Causes of Bronchiectasis

EP: 6.Airway Clearance Techniques and Antibiotics for Patients With Bronchiectasis

EP: 7.Unmet Needs for Bronchiectasis Exacerbations

EP: 8.Ideal Candidates for Bronchiectasis Surgeries

EP: 9.Preventive Strategies and Emerging Therapies for Bronchiectasis

EP: 10.Current Challenges in the Management of Bronchiectasis

EP: 11.The Effects of the Heterogeneity of Bronchiectasis

EP: 12.Novel Treatment Options for Bronchiectasis

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EP: 13.Important Clinical Considerations for Patients With Bronchiectasis

EP: 14.Final Thoughts on Bronchiectasis Management

Clinical Brief: Future Directions in Bronchiectasis Research and Care

Main Discussion Topics

• Current research is moving toward precision treatments for specific bronchiectasis phenotypes.
• Development of bronchiectasis Centers of Excellence is improving care coordination.
• Patient support networks provide additional resources beyond medical care.

Key Points for Physicians

• Ongoing clinical trials are investigating the following:
  • DPP1 inhibition and neutrophil cascade modulation
  • Type 2 inflammation therapies
  • Inhaled anti-inflammatory agents
  • CFTR modulators in non–cystic fibrosis (CF) bronchiectasis
• The COPD Foundation has established the following:
  • 27 bronchiectasis and nontuberculous mycobacteria (NTM) Centers of Excellence
  • 6 clinical associate centers
  • Plans to expand to 150-plus centers
• Additional patient resources include the NTM patient support network.

Notable Insights

The field is shifting from simply categorizing bronchiectasis as CF vs non-CF toward more nuanced phenotyping that enables targeted treatment approaches.

Clinical Significance

The establishment of specialized centers and increased research focus on bronchiectasis represents a significant advancement in addressing this previously underrecognized condition.