Panelists discuss how novel targeted therapies for immunoglobulin A (IgA) nephropathy are transforming treatment paradigms by specifically addressing the underlying pathophysiology of the 4-hit cascade rather than broadly suppressing inflammation.
Novel Targeted Therapies in IgA Nephropathy: Paradigm Shift Toward Pathophysiologic Mechanisms
Therapeutic Evolution
Novel targeted therapies for IgA nephropathy (IgAN) represent a fundamental shift from broad immunosuppression to precision medicine approaches that address specific pathophysiologic mechanisms within the 4-hit cascade:
First-Hit Targeted Therapies
Second-Hit Targeted Therapies
Third-Hit Targeted Therapies
Fourth-Hit Targeted Therapies
Clinical Implications
This targeted approach enables the following:
The paradigm shift toward mechanism-based therapies promises to revolutionize IgAN management, potentially modifying disease course rather than merely managing symptoms and complications. This evolution represents a significant advancement in the field of glomerular diseases more broadly.
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