Clinical Impact of IgA Nephropathy and Quality of Life

EP: 1.Advancing IgA Nephropathy Care: Emerging Therapies, Unmet Needs, and Economic Considerations

EP: 2.Introduction to IgA Nephropathy

EP: 3.Pathogenesis of IgA Nephropathy: The 4-Hit Cascade, A Proliferation-Inducing Ligand (APRIL), and cytokines

EP: 4.Diagnosing IgA Nephropathy

EP: 5.Signs and Symptoms of IgA Nephropathy

EP: 6.Challenges in Timely Identification of IgA Nephropathy

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EP: 7.Clinical Impact of IgA Nephropathy and Quality of Life

EP: 8.Overview of Treatment Landscape for IgA Nephropathy: Standard of Care and KDIGO Guidelines

EP: 9.Current Treatments for IgA Nephropathy and the 4-Hit Cascade

EP: 10.Gaps in Patient Care for IgA Nephropathy

EP: 11.Emerging Anti-BAFF and Anti-APRIL Therapies

EP: 12.Emerging Therapies: Other Strategies and Important Considerations

EP: 13.The Promise of Emerging Therapies for IgA Nephropathy and Future KDIGO Guidelines

EP: 14.Sequencing and Individualizing Treatments for IgA Nephropathy

EP: 15.Measuring Success in IgA Nephropathy in Clinical Practice

EP: 16.Economic Impact of IgA Nephropathy for Patients

EP: 17.Early Diagnosis and Cost Mitigation in IgA Nephropathy

EP: 18.Cost Implications of Modulating IgA Nephropathy Disease Course

EP: 19.Patient-Reported Outcomes in the Treatment of IgA Nephropathy

EP: 20.Future Possibilities for Step Therapy in IgA Nephropathy Treatment

EP: 21.Key Managed Care Considerations for IgA Nephropathy Treatment

EP: 22.Key Economic Considerations in IgA Nephropathy: Progression to Chronic Kidney Disease

EP: 23.Closing Thoughts About IgA Nephropathy Treatment

Clinical Impact and Quality of Life in IgA Nephropathy

Disease Burden and Progression

• Progressive kidney disease: 30%-40% of patients develop end-stage kidney disease (ESKD) within 20-30 years of diagnosis
• Variable progression rate: Some patients experience rapid decline in kidney function (5%-10%), while others have stable disease for decades
• Hypertension development: Affects 60%-80% of patients during disease course, requiring long-term management
• Proteinuria burden: Persistent proteinuria > 1g/day significantly increases risk of progression to ESKD
• Recurrent gross hematuria: Episodes may cause acute kidney injury and temporary functional impairment

Quality of Life Impact

• Symptom burden:
  • Fatigue and reduced energy levels, particularly with advancing chronic kidney disease (CKD)
  • Sleep disturbances and insomnia
  • Edema and physical discomfort in those with significant proteinuria
  • Pain during hematuria episodes
• Psychological effects:
  • Anxiety related to uncertain disease prognosis
  • Depression, particularly in patients with progressive disease
  • Stress surrounding family planning and genetic concerns
  • Fear of dialysis and transplantation
• Treatment-related challenges:
  • Medication adverse effects, especially with immunosuppressive therapies
  • Dietary restrictions (sodium, protein) affecting social dining
  • Frequent medical appointments disrupting work and personal life
  • Financial burden of chronic disease management
• Functional limitations:
  • Reduced physical capacity with advancing CKD
  • Work productivity and employment challenges
  • Limitations in physical activities during hematuria episodes
  • Travel restrictions, particularly with advanced disease

Special Considerations

• Young adult onset: Disease typically affects individuals during prime educational, career, and family-building years
• Lifelong management: Need for ongoing monitoring and medication adherence
• Transplant concerns: Disease recurrence posttransplantation (30%-35%)
• Socioeconomic impact: Work absences, disability, and health care costs
• Transition challenges: Pediatric to adult care transitions for early-onset cases

Early intervention focusing on both disease-modifying therapies and quality of life improvements is essential for comprehensive management of IgA nephropathy. Patient education, psychosocial support, and attention to symptom management should complement efforts to preserve kidney function.