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Post hoc analyses of the phase 3 PEGASUS trial found that clinical and hematological improvements were associated with better patient-reported fatigue and physical function outcomes in paroxysmal nocturnal hemoglobinuria, for an overall bettering of health-related quality of life (HRQOL).

A randomized, controlled, experimental study found that a breathing exercise decreased fatigue and daytime sleepiness at the end of the fourth and eighth weeks of an intervention in patients with obstructive sleep apnea (OSA).

In this new study, investigators searched for potential predictors of melanoma thickness, with implications for treatment decisions regarding biopsy and excision margins.

A population-based cohort study of Hispanic Americans found that people who walked more per day had a lower risk of being diagnosed with type 2 diabetes.

US life expectancy fell by nearly a year in 2021 to 76.1 years; Pfizer’s COVID-19 pill reduced the number of hospitalizations and deaths among older adults during the Omicron surge in Israel; current smokers were found to have thicker, heavier, and weaker hearts compared with nonsmokers.

The researchers noted these improvements were seen without an increase in hyperlactatemia risk.

The findings mean it may be feasible to use adult systemic lupus nephritis (SLE) trial data to reduce the data needed for pediatric indications.

With evidence lacking on the role of inflammation in nasal polyposis (NP), this study investigated the role of 2 potential biomarkers in the nasal secretions of patients who have NP concomitant with aspirin-exacerbated respiratory disease.

People with advanced HIV initiating bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) were more likely to reach CD4 cell count levels of 200 cells/mcL or higher compared with those initiating other antiretroviral therapy (ART) regimens.

Sarah Wells Kocsis, MBA, is co-author of the Milken Institute report, “Chronic Kidney Disease: Finding a Path to Prevention, Earlier Detection, and Management.” She spoke to The American Journal of Managed Care® about the findings of the report and how they can be incorporated into care for patients with chronic kidney disease (CKD).

A cohort study found that there was an inverse association between COVID-19 infection and wearing glasses in an unadjusted analysis, although this association was not identified when adjusting for confounders.

House members in South Carolina will debate a total ban on abortions with no exceptions for rape or incest; the World Health Organization claimed that the monkeypox outbreak could be eliminated in Europe, citing slowing case counts; a study found that drinking black tea was associated with lower mortality risk.

Wayne Winegarden, PhD, of the Pacific Research Institute, explains the harm that white bagging policies cause health systems and how replacing them with new measures to boost market competition could help patients.

Patients with atopic dermatitis (AD) were not found to be at greater risk of venous thromboembolism, regardless of Janus kinase inhibitor use, according to this new meta-analysis.

A decade’s worth of retrospective data from over 1 million patients with end-stage renal disease (ESRD) undergoing dialysis showed that psoriasis may be protective against pneumonia in these patients.

This new study investigated risk factors for cardiovascular disease, including heart failure, among hospitalized patients with a recent history of methamphetamine use and priority patient populations to target.

About 1 in 7 people with systematic onset juvenile idiopathic arthritis (SJIA) will not respond to interleukin-1 or interleukin-6 inhibitors.

While cognitive behavioral therapy (CBT) is known to be effective for generalized depression and anxiety, it is only recently that research has begun exploring its specific use in diabetes, including looking at the effects on depression, anxiety, and glycemic control.

Hatim Husain, MD, associate professor in the Department of Medicine at UC San Diego, discuses must-haves for successful biomarker testing in lung cancer—in particular, non–small cell lung cancer (NSCLC)—and how the field is adapting to the targeted treatment needs of its patients.

Lack of state funding and understaffing are threatening the vaccination campaign for novel Omicron-specific booster shots; experts explore the differences between subcutaneous and intradermal delivery of monkeypox vaccines; HHS’ Office for Civil Rights is struggling to manage rising cases of cyberattacks on US health care organizations.

Having a biosimilar on formulary makes it more likely the biosimilar will be adopted. Length of time a biosimilar is on market can impact how likely it is to be added to formulary.

The real-world study adds to previous randomized controlled trial findings suggesting that shorter courses of antibiotic therapy can be sufficient for hospitalized patients with mild or moderate community-acquired pneumonia.

A retrospective study found that adolescents and young adults (AYA) receiving tyrosine kinase inhibitors (TKI) therapy for chronic-phase chronic myeloid leukemia (CML) had similar prognoses to older patients despite also showing higher tumor burden at diagnosis.

New research suggests Nestin expression can help distinguish combined hepatocellular-cholangiocarcinomas (CCAs) from hepatocellular carcinomas and intrahepatic cholangiocarcinomas.

Workers involved in cleaning up the 2010 Deepwater Horizon disaster, the country’s largest oil spill, were 60% more likely to be diagnosed with asthma or experience asthma symptoms 1 to 3 years afterwards, compared with those who were not involved in the cleanup.

In this study, researchers reaffirmed the safety and efficacy of using budesonide to treat eosinophilic esophagitis (EoE).

While past studies have indicated that home-based and center-based cardiac rehabilitation results in similar outcomes for lower-risk patients, information about patients who are more medically complicated and racially and ethnically diverse is unknown.

Patients receiving the quadruplet therapy have continued to show improved responses and higher rates of minimal residual disease (MRD) negativity.

Do-it-yourself (DIY) automated insulin delivery systems have gained rapid uptake, yielding self-reported improvements in glycemic control and quality of life for patients, but creating unique challenges for health care providers (HCPs).