Cytomegalovirus Common in Patients With Ovarian Cancer, May Contribute to Cognitive Impairment
November 19th 2023Researchers noted that it remains unclear whether cytomegalovirus (CMV) infection is a specific cause of worsened cancer-related cognitive impairment (CRCI), or if it is a biomarker for immune suppression.
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In this interview with The American Journal of Managed Care®, Katie Queen, MD, addresses the complexity of obesity as a medical condition, pivoting to virtual care while ensuring that patients who lived in a rural location continued to receive adequate care, and the importance of integrating awareness of obesity and chronic disease prevention into local food culture.
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Advancements Needed in Research on SCD-Associated Pulmonary Hypertension
November 18th 2023To stress the importance of considering pulmonary complications in sickle cell disease (SCD), researchers compiled an overview on the state of research and available treatment options for patients with SCD associated with pulmonary hypertension.
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Telitacicept Efficacious, Safe in Treating Patients With RA, Inadequate MTX Response
November 18th 2023In these phase 3 findings presented at ACR 2023, the safety and efficacy of this drug was proven in American College of Rheumatology-20 (ACR20), ACR50, and Disease Activity Score in 28 joints with Erythrocyte Sedimentation Rate responses.
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Review Explores Link Between Tumor Burden, CAR T-Cell Therapy Efficacy
November 17th 2023A recent review aimed to characterize the relationship between tumor burden and clinical outcomes in patients treated with chimeric antigen receptor (CAR) T-cell therapy, highlighting the potential mechanisms of high tumor burden impacting CAR T-cell failure.
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Researchers Identify Potential Biomarkers for SMA Motor Improvement Following Nusinersen Treatment
November 17th 2023A retrospective, exploratory analysis identifies biomarkers predictive of spinal muscular atrophy (SMA) response to nusinersen and suggests the efficacy of using machine learning algorithms to anticipate patient outcomes.
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Governor Kathy Hochul proposed this week that New York become the first state to require health systems to implement cyber defenses; a new report from the World Health Organization and the CDC highlighted a staggering rise in measles cases and deaths in 2022; a study published this week claimed that more than a tenth of fecal immunochemical tests used for routine colorectal cancer screening could not be processed by labs.
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New Study Links Sphingolipids With Palmitic Acid to Increased Risk of Sudden Cardiac Death
November 17th 2023Plasma ceramides and sphingomyelins with palmitic acid were linked to a 34% and 37% increased risk of sudden cardiac death (SCD) per higher SD of log sphingolipid levels, respectively.
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Olaparib Does Not Improve OS vs Chemo in Recurrent Platinum-Sensitive Ovarian Cancer
November 17th 2023The use of olaparib as a monotherapy or in combination with cediranib did not provide a statistically significance overall survival (OS) benefit compared with standard of care platinum-based chemotherapy in patients with recurrent, platinum-sensitive ovarian cancer.
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Data on Delandistrogene Moxeparvovec Can Inform Future Gene Therapies
November 17th 2023The FDA approved delandistrogene moxeparvovec-rokl (Elevidys, Sarepta Therapeutics) in June to treat Duchenne muscular dystrophy in ambulatory pediatric patients aged 4 through 5 who have a confirmed DMD gene mutation.
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The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction adenocarcinoma.
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Timing of Neurofilament Light Changes May Predict Multiple Sclerosis Worsening
November 16th 2023The reported neurofilament light elevation preceding confirmed disability worsening events highlighted the value of NfL as an early biomarker of disability worsening and points to the existence of different windows of dynamic central nervous system pathology.
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What We’re Reading: Updated Anthrax Guidelines; At-Home STI Test; Veteran Psychedelic Therapy
November 16th 2023The CDC has published updated recommendations for the postexposure prevention and treatment of Bacillus anthracis (anthrax) infection; the FDA has granted marketing approval to an at-home chlamydia and gonorrhea test; lawmakers and Veterans Affairs officials acknowledge the potential for psychedelic drugs to treat veterans’ mental health conditions and prevent suicide.
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