The AJMC® HIV compendium is a comprehensive resource for clinical news and expert insights for the condition, including disparities in care, prevention of infection among at-risk groups, and the importance of viral suppression.
March 12th 2025
Cabotegravir was found to prevent HIV acquisition as a monotherapy pre-exposure prophylaxis (PrEP) and to treat HIV as a combination antiretroviral therapy (ART) in its long-acting injectable form.
HIV Latent Reservoir Forms Near the Time of ART Initiation, Researchers Find
October 14th 2019While antiretroviral therapy (ART) can suppress HIV infection, ART cannot completely eradicate HIV, which remains in a latent reservoir in CD4-positive T cells during treatment; discontinuation of ART leads to rapid rebound of the virus. This reservoir forms even when ART is initiated early on in the infection, and while the most widely accepted model of how the reservoir forms involves infection of a CD4-positive T cell as it transitions to a resting state, the dynamics and timing of the reservoir’s formation have been largely unknown.
Read More
This Week in Managed Care: October 11, 2019
October 11th 2019This week, the top managed care news included an effort by the Trump administration to bolster Medicare Advantage; an abortion case from Louisiana reached the Supreme Court; the study of adapting to changing oxygen levels wins the Nobel Prize.
Watch
California Becomes First State to Make HIV Prevention Medication Accessible Without a Prescription
October 9th 2019Once the bill goes into effect in January 2020, pharmacists will be able to provide pre-exposure prophylaxis for at least a 30-day supply and up to a 60-day supply and a complete course of post-exposure prophylaxis without a prescription.
Read More
FDA Approves Descovy for HIV Prevention in MSM, Transgender Women
October 3rd 2019The FDA has approved Gilead’s second HIV prevention pill, Descovy, for at-risk adults and adolescents weighing at least 35 kg, excluding those who are at risk of HIV due to vaginal sex because the efficacy of Descovy has not been assessed in this population.
Read More
Tuberculosis Preventive Therapy Heightens Risk of Adverse Outcomes in Pregnant Women With HIV
October 3rd 2019The findings indicate that the initiation of tuberculosis preventive therapy isoniazid during pregnancy carries greater risk than initiation of the treatment during the postpartum period.
Read More
New York Governor Andrew Cuomo said that the state is on track to meet its goal of ending the HIV/AIDS epidemic in New York by 2020; lung damage exhibited by some patients as a result of vaping resembles the damage on lungs exposed to chemical spills or harmful gases; a federal judge has ruled that a Philadelphia nonprofit’s plan to open a supervised injection drug site for drug users does not break federal law.
Read More
Observational Study Results Suggest Most HIV–HIV Kidney Transplants Have Long-term Success
October 3rd 2019The study, which followed 51 people with HIV who received kidney transplants from deceased donors with HIV in South Africa, found that the transplants produced long-term success, with high rates of overall survival and kidney graft survival after 5 years.
Read More
Researchers Identify and Silence Long Noncoding RNA Responsible for HIV Replication
September 27th 2019According to the researchers, the long noncoding RNA, when turned off or deleted, eliminates dormant HIV reservoirs that persist even when patients adhere here to their antiretroviral therapy regimen and are virally suppressed.
Read More
This Week in Managed Care: September 20, 2019
September 20th 2019This week, the top managed care stories included Purdue Pharma filing for bankruptcy; new data showing the number of people who get screened for HIV at least once falls far short of what CDC recommends; findings that most US hospital markets are now highly concentrated.
Watch
Initiating Treatment in EDs Could Be Critical for Containing Spread of HIV
September 19th 2019The researchers of the study argue that emergency departments (EDs) should not just be leveraged to diagnose HIV; they must also be proactive and initiate treatment, as well as facilitate follow-up case management and linkage to care outside of the ED.
Read More
HIV Associated With Significantly Increased Risk of Atrial Fibrillation
September 16th 2019The researchers found that HIV significantly increases the risk of atrial fibrillation—a leading cause of stroke—at the same rate as or higher than known risk factors, including diabetes and hypertension.
Read More
How Many People Actually Get Screened for HIV?
September 14th 2019Using national electronic health record information on more than 40 million patients over a 20-year period, researchers have found that the proportion of Americans older than 18 years who have had a prior HIV test could be as low as 6.4%. However, they noted several limitations of their analysis.
Read More
This Week in Managed Care: August 30, 2019
August 30th 2019This week, the top managed care stories included a huge ruling against one opioid maker and a settlement offer from another; an expert panel calling for broader screening for hepatitis C; a review showing there are more fatal events linked to a multiple sclerosis drug than previously known.
Watch
People Living With HIV in New York City Still Dying From Infections, Not Just Old Age
August 30th 2019The researchers, who used autopsy reports of 252 people who died of AIDS in New York City between 1984 and 2016, found that infections associated with the virus are still the leading cause of death for the patient population in the state.
Read More
This Week in Managed Care: August 16, 2019
August 16th 2019This week, the top managed care stories included the Trump administration looking to bar legal immigrants from using public benefits; a study in The American Journal of Managed Care® finding that a law to limit surprise medical bills is working; data on Affordable Care Act enrollment showing the effect of subsidies.
Watch
Opioid Injection in Rural Areas Presents a Challenge to Ending HIV Epidemic in US
August 13th 2019The viewpoint paints a picture of a challenge that is 2-fold: a growing amount of people are injecting opioids in rural communities, which is an emerging risk factor for HIV transmission, and these communities often lack the infrastructure or resources to prevent, diagnose, and treat HIV.
Read More
For Children Born With HIV, Medication Adherence, Viral Suppression Decreases With Age
August 6th 2019From preadolescence to young adulthood, the rate of self-reported nonadherence increased from 31% to half of study participants. Concurrently, the prevalence of a detectable viral load increased from 16% to 40%.
Read More
Federal regulators have caught on to a growing trend of clinical trials asking participants to pay to enroll; Canada's main pharmaceutical lobby group is asking the government to respond to US drug importation plans before Canada experiences drug shortages; with more HIV incidence than any other region, the South is turning to telemedicine to treat people living with the infection.
Read More