The HFrEF Standard of Care

EP: 1.Heart Failure Clinical and Economic Burden

EP: 2.The Progressive Nature of Heart Failure

EP: 3.Link Between LVEF, NT-ProBNP and Cardiac Remodeling

EP: 4.Improved Understanding of Heart Failure

EP: 5.Treatment Goals for Patients With Heart Failure

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EP: 6.The HFrEF Standard of Care

EP: 7.Heart Failure Management Unmet Needs

EP: 8.Utilization Management Strategies for Appropriate Treatment

EP: 9.Challenges in the Management of HFpEF

EP: 10.Differences in Standard of Care: HFpEF vs HFrEF

EP: 11.Ensuring Timely and Appropriate Access to Therapy

EP: 12.Differences in Economic Burden: HFpEF and HFrEF

EP: 13.PROVE-HF Trial Overview

EP: 14.PARAGON-HF Trial Overview

EP: 15.Recent Findings from the PARALLAX Study

EP: 16.Promising Findings From the TOPCAT Study

EP: 17.Differences in Leading Treatments for Heart Failure

EP: 18.When to Add an SGLT2 Inhibitor to Treatment Regimen

EP: 19.Heart Failure Sites of Care

EP: 20.How Approved Agents Will Change the Standard of Care

EP: 21.Heart Failure Management During COVID-19

John McMurray, MBChB: In patients with heart failure and reduced ejection fraction, we have what some people have recently been calling the 5 alive: the 5 pharmacological approaches that improve survival. These can be given in 4 pills. First is a renal angiotensin system blocker. Today we would couple that with a neprilysin inhibitor, and those 2 treatments can be prescribed in 1 pill: sacubitril-valsartan. Next is a beta-blocker with a mineral corticoid receptor antagonist or aldosterone antagonist. Most recently, the fifth of those pharmacological approaches is an SGLT2 inhibitor. In addition, we have other drugs that improve symptoms and reduce the risk of heart failure hospitalization, but they don’t reduce mortality. Good examples of that would be ivabradine, digoxin, and most recently, a treatment called vericiguat. We may see also new ideas about intravenous iron very shortly, so that may also be added to that list. We also have devices that we use selectively in certain patients that improve survival, and these are implantable cardioverter variation defibrillators and cardiac resynchronization therapy. We’ve got a wealth of life-saving treatments, and a wealth of treatments that improve symptoms and reduce hospital admission.