Step-Up Dosing Protocols and Infection Prevention Strategies for Bispecifics in B-Cell Lymphomas

January 31, 2025

Ryan Haumschild, PharmD, MS, MBA, CPEL
John Allan, MD

Opinion

Video

Panelists discuss how step-up dosing protocols reduce cytokine release syndrome (CRS) risk in patients with high-risk disease and when modifications might be necessary as well as the incorporation of infection prevention strategies, including prophylactic antimicrobials, into management plans.

EP: 1.ASH 2024 Updates on Bispecific Therapies in B-Cell Lymphomas

EP: 2.Emerging Data for Odronextamab in DLBCL

EP: 3.Sequencing Consequences for Earlier Line Use of Bispecifics in B-Cell Lymphomas

EP: 4.Exploring Bispecifics in Earlier Lines of Therapy for B-Cell Lymphomas

EP: 5.ASH 2024 Highlights: Bispecifics in Combination Therapies for B-Cell Lymphomas

EP: 6.MAIC Analyses and Bispecific Therapies: Guiding Treatment Decisions in B-Cell Lymphomas

EP: 7.Understanding CRS and ICANS: Real-World Incidence and Key Patient Risk Factors

EP: 8.Key Strategies for Preventing CRS and ICANS

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EP: 9.Step-Up Dosing Protocols and Infection Prevention Strategies for Bispecifics in B-Cell Lymphomas

EP: 10.Overcoming Logistical Hurdles in Bispecific Therapy Implementation

Video content above is prompted by the following:

How do step-up dosing protocols reduce CRS risk in patients with high-risk disease, and when might you modify this approach? (Dr Allan)
How do you incorporate infection prevention strategies, such as prophylactic antimicrobials, into your management plans? (Dr Graff)