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Phase 3 Checkmate-025, Evaluating Nivolumab in RCC, Stopped Early
Nivolumab proved superior to everolimus in improving overall survival in previously treated patients.
In a press release from earlier today, Bristol Myer's Squibb, the developer of nivolumab, announced that the phase 3 Checkmate-025 trial was halted early by an independent Data Monitoring Committee following significantly better overall survival of patients receiving nivolumab, compared with the control. The trial was evaluating the efficacy of nivolumab versus everolimus in previously treated renal cell carcinoma patients.
“Through our Opdivo clinical development program, we aim to redefine treatment expectations for patients with advanced RCC by providing improved survival,” said Michael Giordano, senior vice president, Head of Development, Oncology, Bristol-Myers Squibb.
Read the complete press release here: http://bit.ly/1LxXiK6
High HSP60 Expression Signals Poor Prognosis, Aggressive Tumors in Ovarian Cancer
January 16th 2025High heat shock protein 60 (HSP60) expression in patients with ovarian cancer is associated with larger tumors, advanced stages, and worse survival outcomes, highlighting its potential as a prognostic biomarker.
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Real-World Evidence Confirms the Benefits of JAK Inhibitors in Patients With Rheumatoid Arthritis
January 16th 2025This systematic review of real-world observational studies demonstrated the effectiveness of Janus kinase (JAK) inhibitors in improving treatment adherence, persistence, clinical outcomes, and patient-reported outcomes among US patients with rheumatoid arthritis.
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