- Center on Health Equity & Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
Overview of BCG-Unresponsive Bladder Cancer Treatments Landscape
Discussion on current and future treatments for BCG-unresponsive HR NMIBC presented at ESMO 2023.
EP: 1.Biomarkers and Molecular/ Genomic Testing in Genitourinary Cancers
EP: 2.Bladder Cancer with FGFR Alterations: THOR-2 Cohort 1 Study at ESMO 2023
EP: 3.Overview of BCG-Unresponsive Bladder Cancer Treatments Landscape
EP: 4.ESMO 2023 Insights: SunRISe-1 Study of TAR-200 in BCG-Unresponsive Bladder Cancer
EP: 5.Key Highlights from EV-302 Study at ESMO 2023
EP: 6.LITESPARK-003 Trial Insights: Updates from ESMO 2023
EP: 7.Future Opportunities in Genitourinary Cancers
This is a video synopsis/summary of a panel discussion involving Sia Daneshmand, MD.
Daneshmand discusses treatment options for BCG-unresponsive non–muscle invasive bladder cancer. Though radical cystectomy cures most patients, it has high morbidity/mortality risks, especially in elderly patients. Alternatives are needed.
If a clinical trial is unavailable or unwanted, options include doublet chemotherapy with gemcitabine plus docetaxel chemotherapy or pembrolizumab immunotherapy. Retrospective data shows 50% 2-year recurrence-free survival with gemcitabine/docetaxel. Pembrolizumab has 25% to 40% response rates.
Valrubicin, the first FDA-approved drug in this setting, has a poor 10% to 15% 1-year recurrence-free survival. More recent options include nadofaragene firadenovec. the first intravesical gene therapy (once every 3 months) with 25% to 40% 1-year recurrence-free survival.
Daneshmand notes clinical trials remain the preferred option, but new FDA-approved treatments provide alternatives for BCG-unresponsive patients. He is excited about the increasing options for this patient population.
Video synopsis is AI-generated and reviewed by AJMCÒ editorial staff.
Lp(a) and Getting a Head Start Against Heart Disease: Jeremy Wigginton, MD
April 8th 2025Lipoprotein a (Lp[a]) is a valuable tool for assessing a patient's risk of cardiovascular disease, which can facilitate earlier intervention efforts and reduce health care costs, argued Jeremy Wigginton, MD.
Read More
Worse CTD-PAH Prognosis Seen With Higher HFA-PEFF Score
April 8th 2025The findings from this single-center retrospective study compare outcomes between 2 groups of patients living with connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) stratified by their Heart Failure Association–preserved ejection fraction (HFA-PEFF) algorithm score.
Read More
Guselkumab Shows Sustained Efficacy in Phase 3b APEX Study for Active PsA
April 8th 2025Long-term extension analysis of the phase 3b APEX study (NCT04882098) through 3 years of treatment will further assess the sustained efficacy of guselkumab (Tremfya; Johnson & Johnson) in limiting structural damage in patients with active psoriatic arthritis (PsA).
Read More
