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NRAS Mutations in Melanoma
Richard W. Joseph, MD, highlights clinical trial results showing that melanoma patients with NRAS mutations tend to have better response rates to immunotherapy compared with patients with wild-type NRAS. NRAS mutations may be valuable predictors of response in patients with melanoma, suggests Dr Joseph.
Dr Joseph discusses previous research that investigated whether response rates for patients treated with high-dose interleukin-2 varied based on whether the patient had an NRAS mutation, a BRAF mutation, or were wild-type for both NRAS and BRAF. The results showed that patients with NRAS mutations responded better to treatment than patients with BRAF mutations or patients who were wild-type for both NRAS and BRAF. More recent research has demonstrated that patients with NRAS mutations also respond better when treated with other types of immunotherapies, he adds.
Although these results are exciting, there is still no definitive answer as to why melanoma patients with NRAS mutations respond better than patients without such mutations, remarks Dr Joseph. He is hopeful that additional studies will provide additional insight into the role of NRAS mutations in melanoma.
Real-World Data Support Luspatercept vs ESAs for Anemia in Lower-Risk MDS
June 5th 2025Patients with myelodysplastic syndrome (MDS) who received luspatercept showed greater hemoglobin gains and transfusion independence compared with erythropoiesis-stimulating agents (ESAs) in a real-world analysis.
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At EHA 2025, Hematology Discussions Will Stretch Across Lifespans and Locations
June 5th 2025The 2025 European Hematology Association (EHA) Congress, convening virtually and in Milan, Italy, from June 12 to June 15, 2025, will feature a revamped program structure for the meeting’s 30th anniversary while maintaining ample opportunities to network, debate, and absorb practice-changing findings in hematology and oncology.
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Laundromats as a New Frontier in Community Health, Medicaid Outreach
May 29th 2025Lindsey Leininger, PhD, and Allister Chang, MPA, highlight the potential of laundromats as accessible, community-based settings to support Medicaid outreach, foster trust, and connect families with essential health and social services.
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Use of Voluntary Alignment in the Next Generation ACO Model
June 5th 2025Use of voluntary alignment attribution by Next Generation Accountable Care Organization (ACO) participants was limited. The authors highlight the reasons and describe organizational use cases via a mixed-methods approach.
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