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Mutation May Be Associated With Resistance to NSCLC Immunotherapy
A specific mutation has been linked with acquired resistance in immunotherapy drugs used to treat non–small lung cancer (NSCLC).
A specific mutation has been linked with acquired resistance in immunotherapy drugs used to treat non—small lung cancer (NSCLC).
Researchers led by cancer biologist Katerina Politi, PhD, associate professor in the Yale Department of Pathology and Medical Oncology, have discovered that a mutation in a viral protein called B2M prevents the immune activation needed for immunotherapy agents to function. The discovery of this new resistance mechanism explains why some patients develop resistance later on in treatment and may also steer the evolution of future NSCLC drug development.1
For patients with NSCLC who are not candidates for other targeted therapies, immunotherapy is considered to be a viable treatment alternative. Immunotherapy drugs that have earned FDA approval to treat NSCLC include breakthrough therapies like nivolumab and pembrolizumab, as well as the most recent agent, atezolizumab.
With Hidradenitis Suppurativa, Maternal and Offspring Outcomes May Suffer
October 31st 2024Novel evidence has emerged from a 16-year study that hidradenitis suppurativa can elevate risks of not only pregnancy and postpartum complications, but of morbidity—particularly metabolic- and immunology-related morbidity—for mother and child in the long term.
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Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Low Pulmonary Rehabilitation, Palliative Care Referrals for Patients With IPF Persist
October 30th 2024Despite proven benefits, referrals to pulmonary rehabilitation and palliative care for patients with idiopathic pulmonary fibrosis (IPF) in England remain significantly lower than for other respiratory conditions.
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New AI Tool Identifies Undiagnosed PNH in Health Records
October 30th 2024The machine learning model shows promise in detecting paroxysmal nocturnal hemoglobinuria (PNH) by assessing electronic health records (EHR) data, potentially transforming the diagnostic landscape for rare diseases.
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