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Gepotidacin vs Nitrofurantoin in uUTI: Study Overview and Clinical Implications
Wendy Cheng, PhD, MPH, discusses how the study on the efficacy of gepotidacin vs nitrofurantoin in a nitrofurantoin-resistant population (a pooled analysis of the EAGLE-2 and EAGLE-3 trials) aimed to evaluate the effectiveness of gepotidacin as a first-in-class oral therapy for uncomplicated urinary tract infections (uUTIs), showing promising results in overcoming antimicrobial resistance and potentially filling critical gaps in current UTI treatments.
EP: 1.Unmet Needs in the Management of UTIs
EP: 2.Gepotidacin vs Nitrofurantoin in uUTI: Study Overview and Clinical Implications
EP: 3.Rethinking Uncomplicated UTI Treatment: Discussion of Aminoglycosides as an Alternative to Carbapenems
EP: 4.Comparing Treatment Options for Acute Pyelonephritis From a Meta-Analysis
EP: 5.Addressing Unmet Needs and Future Outlooks in Treatment of Uncomplicated UTI
Video content above is prompted by the following:
- Briefly describe the study on the efficacy of gepotidacin vs nitrofurantoin in a nitrofurantoin-resistant population: a pooled analysis of the EAGLE-2 and EAGLE-3 randomized controlled trials in uUTI.
- What was the objective of this study?
- How was this study designed? What methodology was used?
- What results were presented?
- Provide your key takeaways from this study. How do the findings contribute to our understanding of uUTIs and antimicrobial resistance, and what role might this first-in-class oral therapy play in addressing current gaps in the treatment landscape?
5 Things Everyone Should Know for National Immunization Awareness Month
August 1st 2025National Immunization Awareness Month highlights the importance of lifelong vaccination to prevent diseases, a practice that has averted millions of deaths, proven to be a cost-effective public health strategy, and offers crucial protection even to individuals who are immunocompromised.
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Politics vs Science: The Future of US Public Health
February 4th 2025On this episode of Managed Care Cast, we speak with Perry N. Halkitis, PhD, MS, MPH, dean of the Rutgers School of Public Health, on the public health implications of the US withdrawal from the World Health Organization and the role of public health leaders in advocating for science and health.
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Updated mRNA Vaccines Against JN.1 Show Strong Safety Signal in Real-World Data
July 31st 2025A nationwide Danish cohort study demonstrated no increased risk of serious adverse events following vaccination with JN.1-updated mRNA COVID-19 vaccines, reinforcing their safety profile and supporting continued use in high-risk populations amid ongoing viral evolution.
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Bird Flu Risks, Myths, and Prevention Strategies: A Conversation With the NFID's Dr Robert Hopkins
January 21st 2025Joining us for this episode of Managed Care Cast is Robert H. Hopkins Jr, MD, medical director at the National Foundation for Infectious Diseases (NFID), who will help separate fact from fiction about avian influenza and discuss what needs to be done to prevent a future escalation.
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Breaking Down Barriers to Hepatitis Elimination on World Hepatitis Day 2025
July 25th 2025World Hepatitis Day 2025 and its theme, “Hepatitis: Let’s Break It Down,” emphasize the urgent need to remove barriers to prevention, testing, and treatment to reduce liver cancer and eliminate hepatitis by 2030.
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