Mark Lebwohl, MD, details how he extrapolates clinical data in his decision-making when trying to treat patients with psoriasis.
Ryan Haumschild, PharmD, MS, MBA: Given examples of some of the long-term follow-up or resurface data, at your organization how do you utilize or prioritize this extrapolation of primary literature as part of your decision-making process for your unique patients?
Mark Lebwohl, MD: I will say first of all, if somebody again had squamous cell carcinoma, they’re not going to get a TNF [tumor necrosis factor] blocker. If they’ve had multiple sclerosis, they’re not going to get a TNF blocker. If they’ve had Crohn disease, they’re not going to get an IL-17 [interleukin-17] blocker. In terms of metabolic syndrome and the factors that go into it, the average weight of those patients makes the less effective treatments we have poorer choices for them. It’s the kind of prescription that will almost for sure lead to a switch. Thus, knowing in advance that it’s going to lead to a switch, why would we prescribe those?
On the other hand, if a patient has psoriatic arthritis and inflammatory bowel disease, the best choices for psoriatic arthritis are TNF blockers and IL-17 blockers. There, if they have inflammatory bowel disease, I’m not going to give them an IL-17 blocker. Those patients are very good choices for TNF blockers. You have to take the whole picture into consideration when you figure out which drug you’re going to give to which patient.
This transcript has been edited for clarity.
Real-World Data Show Bevacizumab Benefits Only High-Risk Patients With Epithelial Ovarian Cancer
May 13th 2025In line with previous clinical trial findings, real-world data show that bevacizumab improves outcomes in patients with epithelial ovarian cancer and high-risk prognostic factors.
Read More
For Patients Who Cannot Wait, This Off-the-Shelf CAR NK Treatment for AML Leaves Healthy Cells Alone
May 12th 2025First part of a 2-part interview with Stephen Strickland, MD, MSCI, director of leukemia research for Sarah Cannon Research Institute. Strickland recently presented data from a phase 1 trial of SENTI-202, an investigational chimeric antigen receptor (CAR) natural killer (NK) cell therapy.
Read More