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Exploring Results from CAPItello-291 Trial
William J. Gradishar, MD, examines the impact of the CAPItello-291 phase III trial on NCCN breast cancer guidelines, comparing the investigated drug to other PI3K pathway inhibitors and discussing its potential to shape future treatment strategies.
EP: 1.NCCN Guidelines Recommend Capivasertib, Fulvestrant for Certain Patients With Breast Cancer
EP: 2.Breast Cancer Treatment: NCCN Guideline Updates and Optimism at ASCO 2024
EP: 3.Sequencing CDK4/6 Inhibitors in HR+/HER2- Breast Cancer Treatment
EP: 4.Tailoring CDK4/6 Inhibitor Treatment to Patient Needs
EP: 5.NCCN Guidelines for Early-Stage Breast Cancer: Abemaciclib and Ribociclib
EP: 6.Exploring Results from CAPItello-291 Trial
EP: 7.Exploring Biomarker Testing and Personalized Treatments in Breast Cancer
EP: 8.NCCN Guidelines Revisions and ASCO 2024 Research Outlook
EP: 9.Emerging Breast Cancer Therapies and Closing Thoughts
- In November 2023, capivasertib received FDA approval for use in advanced hormone receptor-positive breast cancer based on the results from the CAPItello-291 phase III trial. How has capivasertib been integrated into the NCCN guidelines for breast cancer?
- What are your thoughts on sequencing of capivasertib use in the management of HR+ breast cancer?
- How does capivasertib compare to other PI3K pathway inhibitors alpelisib and inavolisib from safety and efficacy standpoints?
STEER Data Open Door to SMA Gene Therapy for Wider Age Range of Children
March 19th 2025Delivery of onasemnogene abeparvovec into the intrathecal space was safe and effective for children with spinal muscular atrophy (SMA) aged 2 to 17 years, who had previously been shut out of receiving gene therapy.
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Bustling Gene Therapy Pipeline for Neuromuscular Diseases Brings Thorny Questions to the Clinic
March 18th 2025The rapid development of gene therapy options for treating neuromuscular diseases has created new therapeutic options but also logistical hurdles and a need for complex discussions between clinicians and families.
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