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Episode 13 - Challenges of Measuring the Outcomes of SLE
During this segment, the panelists discuss treatment options for systemic lupus erythematosus (SLE) and recognize unmet treatment needs from the perspectives of the patient, provider, and payer. To improve patient outcomes, the panelists explore different ways in which treatment for SLE can be improved.
Hugh Fatodu, RPh, MBA, explains that agents currently used to treat SLE are accompanied with adverse events that affect patient adherence, and results of therapy have proven inconsistent amongst certain subgroups of patients. Therefore, clinicians currently question the ability of these agents to provide benefits to their patients.
Michelle Petri, MD, MPH, explains the ways in which long-term exposure of prednisone affects patient outcomes. Dr Petri also believes that a personalized treatment approach is necessary when treating patients.
And because long-term data is still lacking, Maria Lopes, MD, MS, believes that an early diagnosis of SLE is essential, as outcomes of severe SLE are more dangerous.
A meta-analysis showed that control group outcomes in psilocybin trials for depression were significantly weaker than those in selective serotonin reuptake inhibitor (SSRI) and esketamine trials, suggesting that psilocybin’s large observed treatment effects may be inflated by methodological factors such as functional unblinding and expectancy bias.
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LLMs Show Promise, But Challenges Remain in Improving Inefficient Clinical Trial Screening
July 31st 2025Large language models (LLMs) such as GPT-3.5 and GPT-4 may offer a solution to the costly and inefficient process of manual clinical trial screening, which is often hindered by the inability of structured electronic health record data to capture all necessary criteria.
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Trends in Insulin Out-of-Pocket Costs and Use Disparities, 2008-2021
July 31st 2025Given trends in cost and use, insulin out-of-pocket cost reduction policies would be more efficient if they targeted members in high-deductible health plans with savings options and low-income patients.
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Legal Navigation Services Key to Addressing Disparities in Cancer Care
July 31st 2025A significant number of patients with cancer, caregivers, and health care professionals face significant disparities in legal issues, with the most common needs revolving around health insurance, finances, employment, and disability insurance.
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