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Elotuzumab Combo Delays Myeloma Progression in Phase 3 Trial
A presscast held prior to the annual meeting of the American Society of Clincal Oncology presented interim results from the phase 3 ELOQUENT-2 trial. Adding elotuzumab to lenalidomide and dexamethasone reduced the risk of disease progression by 30% in patients with relapsed-refractory multiple myeloma.
Adding elotuzumab to lenalidomide (Revlimid) and dexamethasone reduced the risk of disease progression by 30% in patients with relapsed-refractory multiple myeloma (RRMM), according to interim results from the phase 3 ELOQUENT-2 trial. The data, which were presented during a presscast held in advance of the 2015 annual meeting of the American Society of Clinical Oncology (ASCO), showed that combining the monoclonal antibody with standard care prolonged remission by 4.5 months.
“Based on this randomized phase 3 trial, we hope that we will soon have a new treatment option for patients with relapsed or refractory myeloma where an immune therapy—based approach can be added with lenalidomide and dexamethasone for the management of these patients,” said lead author Sagar Lonial, MD, chief medical officer of the Winship Cancer Institute of Emory University, and professor and executive vice chair o the department of hematology and medical oncology of Emory University School of Medicine.
Elotuzumab, which is being developed by Bristol-Myers Squibb and AbbVie, binds to the SLAMF7 protein found on the surface of both myeloma cells and natural killer lymphocytes in the immune system. “One of the unique attributes of elotuzumab is that it appears to have a dual mechanism through which it both targets the myeloma cell and appears to enhance the activation of natural killer cells,” said Lonial.
Read more at OncLive.
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Linking Data to Determine Risk for 30-Day Readmissions in Dementia
December 22nd 2025This study found that certain characteristics in linked electronic health record data across episodes of care can help identify patients with Alzheimer disease and related dementias at high risk of 30-day readmissions.
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Performance of 2-Stage Health-Related Social Needs Screening Using Area-Level Measures
December 19th 2025Limiting health-related social needs screening to lower-income areas would reduce screening burdens; however, this study found a 2-stage screening approach based on geography to be suboptimal.
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