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Dr James Howard on the Complications of Standard Myasthenia Gravis Therapies
Current myasthenia gravis therapies can exacerbate comorbidities or create other complications, said James F. Howard Jr, MD, professor of neurology at the University of North Carolina at Chapel Hill.
Current myasthenia gravis therapies can create other complications, said James F. Howard Jr, MD, professor of neurology at the University of North Carolina at Chapel Hill, former chief of the Neuromuscular Disorders Division, and former James F. Howard Distinguished Professor of Neuromuscular Disease.
Transcript
Can comorbidities in myasthenia gravis be worsened by current therapies such as prednisone, for example?
Yes. I mean, with prednisone, we worry about the development of diabetes, of hypertension, osteopenia and osteoporosis—thinning of the bones, if you will—to say nothing of the mood changes that people experience when they take this drug. Other drugs have the potential to impact the liver, for instance. Others have potential impact on the ability to form blood cells. Not every patient experiences them, and some patients are successfully treated with very minimal side effects. But in the whole, in the majority, these happen to such a degree that we don't like them and we need to find better.
Inside the Center's MDD Value Model and Its Use of Dynamic Pricing
May 13th 2025Larragem Raines, MS, of the Center for Innovation & Value Research, discusses the organization's major depressive disorder (MDD) open-source value model, dynamic pricing, and the future role of artificial intelligence in care.
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