CROI 2025 Insights: Evolving HIV Treatment Landscape and Practice-Changing Developments

EP: 1.HIV Viral Suppression: Clinical Significance and Impact on Patient Outcomes

EP: 2.Changing Patient Demographics in HIV and Impacts of Polypharmacy on Treatment

EP: 3.Phase 3 HIV Treatment Switch Studies: Key Findings From Recent Clinical Trials

EP: 4.HIV Therapy Without Integrase Inhibitor: Practical Advantages and Targeted Patient Populations

EP: 5.Long-Acting HIV Therapies: Real-World Data and Clinical Application

EP: 6.CD4 T-cell and Lymphocyte Monitoring: Clinical Significance in HIV Treatment

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EP: 7.CROI 2025 Insights: Evolving HIV Treatment Landscape and Practice-Changing Developments

Future Directions in HIV Treatment

Key Themes:

• Treatment Evolution: Continuous improvement in HIV medications regarding efficacy, tolerability, and convenience
• Long-Acting Formulations: Development of oral, subcutaneous, intramuscular, and intravenous options
• Combination Products: Future devices potentially combining HIV treatment/prevention with contraception or sexually transmitted infection prevention
• HIV Prevention: New preventive therapies potentially effective for 1 to 2 years

Notable Insights from Dr Sharon Walmsley:

• Long-acting therapies help “demedicalize” HIV by reducing medication frequency.
• New challenges in adherence emerge with transition from daily to weekly or monthly dosing schedules.
• HIV treatment advances have informed approaches to other infectious diseases, including COVID-19 and Mpox.
• Despite prevention advances, questions remain about whether to continue vaccine development efforts given limited success to date.