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Computed Tomography Perfusion [CTP] In Stroke Management
Kevin Sheth, MD, discusses the role of computed tomography perfusion amid stroke diagnosis.
This is a video synopsis/summary of a Post Conference Perspectives involving Kevin Sheth, MD.
This is a video discussing the role of CT perfusion in the management of ischemic stroke patients, specifically focusing on an abstract presented regarding mechanical thrombectomy in ischemic stroke patients without salvageable brain tissue based on CT perfusion imaging.
Sheth explains that at Yale, CT perfusion is part of the routine clinical evaluation of acute stroke patients. It provides quantitative assessment of the infarct core and penumbral tissue to verify stroke diagnosis, characterize stroke severity, assist in family discussions, and guide potential interventions.
The methods of the discussed observational study involved evaluating multimodal CT scans, including CT perfusion, in ischemic stroke patients to develop mismatch profiles quantifying infarct core and penumbral tissue. These were related to details of endovascular treatment and functional independence at 90 days. Statistical adjustments were made for baseline differences.
Key findings were an interaction between recanalization status, age, and infarct extent, suggesting mechanical thrombectomy may be most effective in patients under 70 years old with moderate infarct volumes. Propensity score matching analyses in subgroups showed similar functional independence rates between patients.
Video synopsis is AI-generated and reviewed by AJMC editorial staff.
Managed Care Reflections: A Q&A With A. Mark Fendrick, MD, and Michael E. Chernew, PhD
December 2nd 2025To mark the 30th anniversary of The American Journal of Managed Care (AJMC), each issue in 2025 includes a special feature: reflections from a thought leader on what has changed—and what has not—over the past 3 decades and what’s next for managed care. The December issue features a conversation with AJMC Co–Editors in Chief A. Mark Fendrick, MD, director of the Center for Value-Based Insurance Design and a professor at the University of Michigan in Ann Arbor; and Michael E. Chernew, PhD, the Leonard D. Schaeffer Professor of Health Care Policy and the director of the Healthcare Markets and Regulation Lab at Harvard Medical School in Boston, Massachusetts.
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