Teclistamab-Daratumumab Outperforms Standard of Care for R/R Multiple Myeloma
January 15th 2026Teclistamab plus daratumumab delivers unprecedented progression-free survival benefits over standard of care in relapsed/refractory multiple myeloma, while raising important questions about how best to sequence bispecific combinations with CAR T-cell therapy.
Sequencing CAR T-Cell Therapy in the Evolving Myeloma Treatment Landscape
January 15th 2026While earlier-line BCMA CAR T-cell therapy in multiple myeloma offers superior efficacy and longer treatment-free survival, careful monitoring and further research are needed to manage rare but serious toxicities.
Overcoming Operational Barriers to Bispecific Use in Community Oncology
January 15th 2026While implementing bispecific antibodies in community oncology carries a steep learning curve, targeted education and stronger multidisciplinary collaboration can significantly improve clinician confidence and real-world uptake.
Personalized Selection of HER2+ Breast Cancer Therapies
Explore the latest strategies for selecting treatment regimens in HER2-positive breast cancer, focusing on safety and patient-specific factors.
Distinguishing Treatment Resistance from Comorbidity Burden in Depression Care
January 14th 2026Steven Stoner, PharmD, advises managed care teams to use rigorous diagnostic assessments, monitor adherence, and invest heavily in early patient follow-up to accurately attribute costs to treatment-resistant depression.
Defining Success in Metastatic Breast Cancer Trial Design
Explore the latest findings from the KATHERINE, PATINA, and HER2CLIMB-05 trials, highlighting advancements and challenges in breast cancer treatment.
Leveraging Data to Intervene Early in Treatment-Resistant Depression
January 14th 2026Steven Stoner, PharmD, advocates for integrating patient-reported outcomes and digital monitoring to identify early treatment failure and justify utilizing highly effective therapies like dextromethorphan-bupropion sooner.
Evaluating Clinical Trial Data and Real-World Evidence of Bispecific Antibodies in Multiple Myeloma
Explore the unique mechanisms of bispecific antibodies and their rapid availability compared to CAR T-cell therapies in cancer treatment.
Mechanisms of Action of Bispecific Antibodies in Multiple Myeloma
Explore the unique mechanisms of bispecific antibodies versus CAR T-cell therapies in treating multiple myeloma and their clinical implications.
Linking T-Cell Composition to CAR T Efficacy in Multiple Myeloma
January 8th 2026Higher levels of CD4-positive naïve T cells in patients receiving CAR T-cell therapy for multiple myeloma are associated with longer PFS, suggesting T-cell composition may serve as a biomarker to guide patient selection.
ASH 2025 Highlights Reinforce Durability, Safety, and Strategic Sequencing in MCL Therapy
January 8th 2026Michael Wang, MD, reviews ASH 2025 data showing durable safety with long-term BTK inhibition, promising next-generation targeted agents, sustained CAR T-cell efficacy, and evidence favoring upfront combination therapy over sequential treatment in mantle cell lymphoma.
Exploring CAR T-Cell Therapy Efficacy in Earlier Vs Later Lines of Therapy
January 8th 2026Data presented at ASH 2025 suggest earlier-line use of cilta-cel leads to better outcomes in multiple myeloma because patients have fitter immune systems and less exhausted T cells, improving CAR T feasibility, expansion, and durability compared with later-line treatment.
Single Bispecific Strategy Shows Operational Efficiencies, Cost Savings in DLBCL and FL
January 8th 2026Consolidating treatment to a single bispecific antibody for DLBCL and follicular lymphoma can improve operational efficiency and generate cost savings for oncology practices without affecting efficacy or safety.
Interpreting Key Data From KATHERINE, HER2CLIMB-05, and PATINA
Explore the latest findings from the KATHERINE, PATINA, and HER2CLIMB-05 trials, highlighting advancements and challenges in breast cancer treatment.