Data on Delandistrogene Moxeparvovec Can Inform Future Gene Therapies
November 17th 2023The FDA approved delandistrogene moxeparvovec-rokl (Elevidys, Sarepta Therapeutics) in June to treat Duchenne muscular dystrophy in ambulatory pediatric patients aged 4 through 5 who have a confirmed DMD gene mutation.
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The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction adenocarcinoma.
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Timing of Neurofilament Light Changes May Predict Multiple Sclerosis Worsening
November 16th 2023The reported neurofilament light elevation preceding confirmed disability worsening events highlighted the value of NfL as an early biomarker of disability worsening and points to the existence of different windows of dynamic central nervous system pathology.
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What We’re Reading: Updated Anthrax Guidelines; At-Home STI Test; Veteran Psychedelic Therapy
November 16th 2023The CDC has published updated recommendations for the postexposure prevention and treatment of Bacillus anthracis (anthrax) infection; the FDA has granted marketing approval to an at-home chlamydia and gonorrhea test; lawmakers and Veterans Affairs officials acknowledge the potential for psychedelic drugs to treat veterans’ mental health conditions and prevent suicide.
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Remibrutinib Shows Promise for Chronic Spontaneous Urticaria in Phase 3 Trials
November 15th 2023Remibrutinib, an investigational, highly selective Bruton tyrosine kinase inhibitor, showed favorable results in the treatment of chronic spontaneous urticaria (CSU) in as early as 2 weeks in the phase 3 REMIX-1 and REMIX-2 studies.
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Benefits of Excluding Aspirin From Antithrombotic Regimen in Patients With LVADs
November 15th 2023New research highlighted how aspirin is unnecessary in antithrombotic regimens for patients with advanced heart failure and fully magnetically levitated left ventricular assist devices (LVADs).
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What We’re Reading: UnitedHealth Lawsuit; Fentanyl Crackdown; Global Heat Deaths Increase
November 15th 2023A class action lawsuit was filed against UnitedHealth Group and a subsidiary for allegedly using an algorithm to deny rehabilitation coverage for seriously ill patients; US and China officials are finalizing an agreement to crack down on fentanyl; a study published Tuesday projected global heat deaths to increase by 370% if no action is taken against global warming.
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Investigators Explore Potential Link Between the Gut Microbiome and Myasthenia Gravis Risk
November 14th 2023This new study sought to solidify a relationship between certain microbes in intestinal flora and the risk of developing myasthenia gravis, specifically those potentially reducing that risk.
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Study Reveals Racial Disparities in Immune Tolerance Induction Treatment for Hemophilia
November 14th 2023New research highlights racial disparities in hemophilia care, revealing that Black and Hispanic patients are significantly less likely to receive immune tolerance induction treatment compared with White patients, even after considering clinical factors.
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Dr Ruben Mesa Shares How Atrium Health Addresses Health Disparities in Rural, Minority Populations
November 14th 2023Ruben A. Mesa, MD, president and executive director of Atrium Health Levine Cancer Institute and Atrium Health Wake Forest Baptist Comprehensive Cancer Center, discusses key challenges and opportunities for improving cancer care among rural and minority patients.
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Study Identifies Predictors of Fibromyalgia, Chronic Fatigue in IBS Patients
November 14th 2023A retrospective analysis of data from the US National Inpatient Sample revealed the prevalence of fibromyalgia and chronic fatigue syndrome was significantly increased in patients with IBS compared with those without IBS.
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Model Accurately Predicts SCD Pain Scores Using Apple Watch Data
November 14th 2023Patients with sickle cell disease (SCD) who wore an Apple Watch and reported daily pain scores could have their pain scores accurately predicted during hospital admission for vaso-occlusive crises and after discharge.
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COPD Linked to 28-Day All-Cause Mortality in Patients With Sepsis
November 14th 2023Compared with those without chronic obstructive pulmonary disease (COPD), patients with both sepsis and COPD had higher intensive care unit (ICU) mortality rates, longer ICU stays, and higher in-hospital mortality rates.
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