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Treatment Decisions and Unmet Needs
Peter Salgo, MD, and Ira M. Klein, MD, MBA, FACP, discuss the results of the recent Chemohormonal Therapy versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer (CHAARTED) and implications for clinical practice. Also discussed are the factors that clinicians consider when making evidence-based treatment decisions and the need for additional treatment options and clinical trial data.
The CHAARTED trial demonstrated the benefits of docetaxel in addition to androgen-deprivation therapy in patients with metastatic prostate cancer, particularly in patients with high-volume disease. Dr Klein explains that during the treatment decision making process, clinicians take into account a patient’s age and life expectancy. This information is helpful to patients and providers when determining how aggressively to treat a tumor.
As we enter a new generation of androgen suppression and blockade, Dr Klein comments that a higher level of understanding of prostate cancer is needed at the genomic level.
Watch our related Peer Exchange, Oncology Stakeholder Summit 2014: Evidence-Based Decisions to Improve Quality and Regulate Costs
Impact of Amivantamab-Lazertinib on EGFR, MET Resistance Alterations in NSCLC: Danny Nguyen, MD
September 15th 2025The combination of amivantamab and lazertinib in first-line non–small cell lung cancer (NSCLC) significantly reduces resistance mechanisms with implications for second-line treatment, said Danny Nguyen, MD, of City of Hope.
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Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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September 8th 2025Uncommon EGFR mutations in non–small cell lung cancer (NSCLC) remain challenging to treat, but new tyrosine kinase inhibitors, bispecific antibodies, and a proposed “PACCage insert” framework provide opportunities to advance precision therapy.
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Clinical Advances in EGFR-Mutated NSCLC: Insights From MARIPOSA and FLAURA2
September 7th 2025Treatment of EGFR-mutated non–small cell lung cancer (NSCLC) is shifting toward next-generation sequencing and combination regimens that improve survival but increase toxicity, requiring individualized care.
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