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PD-L1: Immunotherapy Response Biomarker in Lung Cancer?
PD-L1 protein levels could be an important biomarker to predict response to immunotherapy in NSCLC patients.
Among patients with non-small cell lung cancer (NSCLC) treated with the investigational immune checkpoint inhibitor MK-3475, those whose tumors had high levels of the protein PD-L1 had significantly better outcomes. These results from a phase I clinical trial were presented at the American Association for Cancer Research 2014 Annual Meeting, in San Diego, California.
Preliminary data from the trial, which were reported earlier this year, showed that MK-3475 treatment was well tolerated and led to durable, objective responses in previously treated patients with NSCLC, particularly those with tumors found to have high levels of PD-L1 prior to treatment.
The latest results extend these data, showing that at 6 months after starting treatment, 41% of patients whose tumors had high levels of PD-L1 had no disease progression, compared with 17% of those whose tumors had low levels of PD-L1. Similarly, 72% of patients whose tumors had high levels of PD-L1 were alive at this time, compared with 53% of those whose tumors had low levels of PD-L1.
Read the complete report here: http://bit.ly/1mQXGWK
Source: OncologyNurseAdvisor
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Texas Oncology to Roll Out Canopy for ePROs After Head-to-Head Pilot
March 18th 2025Debra Patt, MD, PhD, MBA, executive vice president of Public Policy and Strategy for Texas Oncology, said the practice received positive feedback from nurses and patients during a pilot that concluded in February.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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