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Northwestern Study Discovers Treatment For Pediatric Gliomas
The study, published in Nature Medicine, identified a small molecule inhibitor that increases histone methylation, compensating for the reduced methylation caused by mutation in the H3F3A gene, resulting in gliomas.
Researchers at Northwestern Medicine have discovered a new potential drug that shows promise in treating a rare and incurable form of brain tumor in children. When the researchers used an experimental drug called GSKJ4, it inhibited the tumor-forming ability of a specific genetic mutation and prolonged survival in mice models.
Pediatric brainstem glioma, also known as diffuse intrinsic pontine glioma (DIPG), is a type of brain tumor that grows in the brainstem, which controls many of the critical body functions. Due to their location inside the brainstem, these tumors cannot be removed by surgery, nor targeted effectively with radiation or chemotherapy. The disease is thus incurable, and patients survive less than one year with this condition.
"No significant advances in the survival of DIPG patients have been made over the last few decades, and new therapeutic approaches are desperately needed," said first author of the study, Rintaro Hashizume, MD, PhD, assistant professor in neurological surgery at Northwestern University Feinberg School of Medicine.
Complete article on BioProcess Online: http://bit.ly/1riwbpU
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Texas Oncology to Roll Out Canopy for ePROs After Head-to-Head Pilot
March 18th 2025Debra Patt, MD, PhD, MBA, executive vice president of Public Policy and Strategy for Texas Oncology, said the practice received positive feedback from nurses and patients during a pilot that concluded in February.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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