Parkinson’s disease is a common degenerative neurological disease associated with significant disability, poor quality of life, and reduced life expectancy relative to the general population. Present care for this disease is suboptimal, as it is often misdiagnosed and undertreated. Healthcare costs for caring for patients with Parkinson’s disease are high, and will only rise, since the prevalence of this disease promises to increase in years to come. It is of benefit to managed care for clinicians to increase their understanding of this disease and become up-to-date on the best available methods for diagnosis and treatment. In 3 parts, this supplement presents current clinical approaches in Parkinson’s disease, based on the recent clinical literature, evidence-based guidelines, and opinions of various specialists in the field.