Maintenance Therapy With the PARP Inhibitor Olaparib Significantly Improves PFS in Ovarian Cancer
Results of a phase II trial of the PARP inhibitor olaparib, presented at the meeting of the Society of Gynecologic Oncology, showed that maintenance therapy with olaparib significantly improved PFS in ovarian cancer patients.
Patients randomized to olaparib had a 60% improvement in the exploratory endpoint of time to first subsequent therapy or death (TFST) as compared with placebo-treated patients, according to Ursula Matulonis, MD,
of the Dana-Farber Cancer Institute in Boston, and colleagues. Time to second subsequent therapy (TSST) also was significantly prolonged in the olaparib group.
The significant advantage applied to the overall analysis and to subgroup analyses by BRCA mutation status, they reported here at the Society of Gynecologic Oncology meeting.
"In this phase II trial, olaparib maintenance monotherapy led to clinical benefits that persisted beyond the first progression by RECIST criteria," Matulonis said. "Statistically significant improvements in progression-free survival, time to first subsequent therapy, and time to second subsequent therapy, in favor of olaparib, were observed in the overall patient population and in both BRCA-mutant and wild-type subgroups."
"The benefits of olaparib therapy were greatest in the BRCA-mutant subgroup," she added.
Read the complete story here:
http://bit.ly/1guLYjv Source: Medpage Today
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
Listen
Uniting to Support Patients With Cancer Beyond Treatment
November 17th 2024Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.
Read More
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
Bridging Cancer Care Gaps and Overcoming Medical Mistrust
November 13th 2024In this clip from our interview with Oscar B. Lahoud, MD, cochair of our Institute for Value-Based Medicine® evening hosted with NYU Langone Health, he addressed medical mistrust in underrepresented communities.
Read More
How English- and Spanish-Preferring Patients With Cancer Decide on Emergency Care
November 13th 2024Care delivery innovations to help patients with cancer avoid emergency department visits are underused. The authors interviewed English- and Spanish-preferring patients at 2 diverse health systems to understand why.
Read More
