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Literature: Germline BRCA Mutations Increase Susceptibility to Salivary Gland Cancer
The study, published online in JAMA Otolaryngology - Head & Neck Surgery, found a significant increase in the rate of head and neck cancers in individuals carrying a BRCA mutation.
5754 individuals from 187 pedigrees were included in the cohort. Previous research has identified a link between salivary gland cancer and breast cancer, which formed the basis of the current study.
From the 5754 individual cohort, 2 parotid gland cancers, 2 salivary gland cancers not otherwise specified, and 1 adenoid cystic carcinoma were identified.
BRCA
BRCA
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One of these cancers likely did not segregate with the mutation, and another individual tested negative for the mutation, resulting in a rate of 3 of 5754 (0.052%). The observed rate of 3 of 5754 cases (0.052%) of head and neck cancers in -positive probands and likely carriers is significantly higher than the background incidence rate of 3 of 100,000 (0.003%) per year ( < .001).
The Clinical Cancer Genetics Program at The Ohio State University Wexner Medical Center. A total of
In this retrospective review, the authors evaluated several pedigrees of patients who were diagnosed with breast cancer in
Link to the journal article: http://bit.ly/1BAqxUz
Link to Rebecca Nagy's (senior author on the paper) participation in AJMC's panel discussion on genetic counseling: http://bit.ly/1vjffSr
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
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Uniting to Support Patients With Cancer Beyond Treatment
November 17th 2024Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.
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Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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Bridging Cancer Care Gaps and Overcoming Medical Mistrust
November 13th 2024In this clip from our interview with Oscar B. Lahoud, MD, cochair of our Institute for Value-Based Medicine® evening hosted with NYU Langone Health, he addressed medical mistrust in underrepresented communities.
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How English- and Spanish-Preferring Patients With Cancer Decide on Emergency Care
November 13th 2024Care delivery innovations to help patients with cancer avoid emergency department visits are underused. The authors interviewed English- and Spanish-preferring patients at 2 diverse health systems to understand why.
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