- Center on Health Equity & Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
In The Literature: Mesenchymal Stem Cells Suppress Glioblastoma in a Murine Model
In this study, the authors engineered BMP4-secreting mesenchymal stem cells to study their effect on a glioblastoma mouse model.
Glioblastoma is the most common primary intracranial malignant cancer in adults, and is associated with poor outcomes despite multimodality therapy. This lack of effectiveness of current therapies is presumably because of a small subset of tumor cells, so-called brain tumor initiating cells (BTIC), with self-renewal capabilities and stronger tumor-initiating capacities. Mesenchymal stem cells (MSC) have an endogenous tropism toward certain cancers, and adipose tissue provides a feasible and less invasive source of MSCs. Moreover, bone morphogenetic protein (BMP4) has been shown to decrease proliferation by inducing BTIC differentiation. Therefore, adipose-derived MSCs engineered to secrete BMP4 (hAMSCs-BMP4) may be a potential effective treatment option for glioblastoma.
In this study, we show that engineered hAMSC-BMP4 cells reduce the proliferation and migration of glioblastoma and induce differentiation of BTICs in vitro
and in vivo
. Furthermore, a single, cardiac injection of these cells into a mouse model of glioblastoma significantly prolongs survival. These findings suggest that hAMSCs-BMP4 are a promising novel cell-based therapy for patients with glioblastoma and potentially other metastatic cancers.
Read the original paper here:
Source: Clinical Cancer Research
Exploring Racial, Ethnic Disparities in Cancer Care Prior Authorization Decisions
October 24th 2024On this episode of Managed Care Cast, we're talking with the author of a study published in the October 2024 issue of The American Journal of Managed Care® that explored prior authorization decisions in cancer care by race and ethnicity for commercially insured patients.
Listen
Uniting to Support Patients With Cancer Beyond Treatment
November 17th 2024Kasey Bond, MPH, of Perlmutter Cancer Center at NYU Langone Health, speaks to why it’s vital to keep patients at the center of all strategic partnerships between academic institutions and community-based oncology practices.
Read More
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
Bridging Cancer Care Gaps and Overcoming Medical Mistrust
November 13th 2024In this clip from our interview with Oscar B. Lahoud, MD, cochair of our Institute for Value-Based Medicine® evening hosted with NYU Langone Health, he addressed medical mistrust in underrepresented communities.
Read More
How English- and Spanish-Preferring Patients With Cancer Decide on Emergency Care
November 13th 2024Care delivery innovations to help patients with cancer avoid emergency department visits are underused. The authors interviewed English- and Spanish-preferring patients at 2 diverse health systems to understand why.
Read More
